he hemolytic uremic syndrome (HUS) is characterized by the simultaneous occurrence of the triad of acute renal insufficiency, microangiopathic hemolytic anemia and thrombocytopenia. The HUS is the most common cause of acute renal failure in infants and young children in western countries. It could be classified into diarrhea positive, D+ (typical) or diarrhea negative, D(atypical) HUS. In Europ...

A group of guinea pigs carrying a chronic streptococcus cervical lymphadenitis has been studied. The chronic disease may be transmitted with pure cultures of streptococci isolated from the naturally occurring abscesses. Its probable mode of transmission under natural conditions was shown to be the ingestion of the infective agent. The spontaneous appearance of an acutely fatal variant was obser...

Ascending infection of microbes from the lower genital tract into the amniotic cavity increases the risk of preterm birth, stillbirth, and newborn infections. Host defenses that are critical for preventing ascending microbial infection are not completely understood. Group B Streptococcus (GBS) are Gram-positive bacteria that frequently colonize the lower genital tract of healthy women but cause...

A previously healthy 13-month-old boy developed group A beta-hemolytic streptococcus bacteremia coinciding with numerous eruptive subcutaneous lesions primarily on his extremities. Skin biopsy revealed infectious panniculitis; gram-positive cocci were present within both fat lobules and septa. Molecular genetic analysis of an isolate from the patient's blood revealed an emm type 4 organism disp...

The non-hemolytic streptococci of the human throat form, simultaneously, one of the oldest and least known groups of the genus. These familiar but illdefined organisms are usually referred to as the "salivarius group," as "Streptococcus viridars" and "indifferent streptococci" according to the degree of greening produced in blood agar, or simply as the "mouth streptococcus." In their early clas...

Acute pharyngitis is one of the most common illnesses for which children visit primary care physicians. Most cases of acute pharyngitis in children are caused by viruses and are benign and self-limited. Group A beta-hemolytic streptococcus is the most important of the bacterial causes of acute pharyngitis. Strategies for diagnosis and treatment of acute pharyngitis are directed at distinguishin...

autoimmune hemolytic anemia (aiha) is characterized by shortening of red blood cell (rbc) survival and the presence of autoantibodies directed against autologous rbcs. approximately 20% of autoimmune hemolytic anemia cases are associated with cold-reactive antibody. about half of patients with aiha have no underlying associated disease; these cases are termed primary or idiopathic. secondary ca...

The red polyene pigment granadaene was purified and identified from Propionibacterium jensenii. Granadaene has previously been identified only in Streptococcus agalactiae, where the pigment correlates with the hemolytic activity of the bacterium. A connection between hemolytic activity and the production of the red pigment has also been observed in P. jensenii, as nonpigmented strains are nonhe...

background and objectives: accurate designation of antimicrobial susceptibility pattern of the infecting microorganisms is an important crucial factor in making appropriate therapeutic decisions. macrolide, lincosamide and streptogramin b antibiotics are in a family, reserved as an alternative approach in treatment of resistant gram positive cocci. amongst them, clindamycin has been considered ...

Through elaboration of its botulinum toxins, Clostridium botulinum produces clinical syndromes of infant botulism, wound botulism, and other invasive infections. Using comparative genomic analysis, an orphan nine-gene cluster was identified in C. botulinum and the related foodborne pathogen Clostridium sporogenes that resembled the biosynthetic machinery for streptolysin S, a key virulence fact...