A transition metal-free, oxidative, regioselective cross-coupling between non-functionalized azoles and chromones at C2-position was developed. A broad reaction scope and further transformation of products were demonstrated. The biological evaluation of products revealed a novel class of hedgehog signaling pathway inhibitors.

Introduction: Pityriasis versicolor is superficial fungal infection. Topical drugs are often effective in treatment of limited disease while systemic more suitable extensive cases. The triazole drugs, itraconazole and fluconazole have shown promising results at different doses.
 Aims: To assess the efficacy safety oral combined with ketoconazole shampoo versicolor.
 Methods: study was...

In the zwitterionic title compound, C(22)H(25)N(3)S, the benzimid-azole ring system makes a dihedral angle of 55.69 (11)° with the phenyl ring. In the crystal structure, inter- and intra-molecular C-H⋯S inter-actions occur.

OBJECTIVES To analyse the potential antagonism between azoles, which inhibit ergosterol synthesis, and polyenes, which bind directly to ergosterol in cell membranes, in patients receiving sequential azole-polyene treatment. METHODS In an earlier randomized, double blind study of liposomal amphotericin as initial therapy for invasive filamentous fungal infection (IFFI), a 3 mg/kg/day dose had ...

Introduction Compared to antibacterial drugs, antimicrobial agents available for treatment of invasive fungal infections are sparse. Amphotericin B (polyene) was the first drug introduced in the 1950s, followed by flucytosine (pyrimidine) in the 1970s, and first-generations azoles (fluconazole, itraconazole) in the 1990s. Triazoles (voriconazole, posaconalzole) and echinocandins (caspofungin, m...