نتایج جستجو برای: azgh 102
تعداد نتایج: 24427 فیلتر نتایج به سال:
BACKGROUND A herbal preparation, known as RMIT Chinese Medicine 102 (RCM-102) consisting of eight herbs which demonstrates inhibition of the release of key inflammatory mediators associated with seasonal allergic rhinitis (SAR) was used. This study evaluated the efficacy and safety of RCM-102 for SAR. OBJECTIVE This study evaluated the efficacy and safety of RCM-102 for SAR. METHODS This ra...
BACKGROUND Early clinical trials conducted primarily in Japan have shown that TAS-102, an oral agent that combines trifluridine and tipiracil hydrochloride, was effective in the treatment of refractory colorectal cancer. We conducted a phase 3 trial to further assess the efficacy and safety of TAS-102 in a global population of such patients. METHODS In this double-blind study, we randomly ass...
BACKGROUND TAS-102 improves overall survival (OS) in patients with metastatic colorectal cancer (mCRC) refractory to standard treatments. However, predictive biomarkers of efficacy are currently lacking. PATIENTS AND METHODS We treated a cohort of 43 chemorefractory mCRC patients treated with TAS-102, in a single institution expanded access, compassionate use programme. We stratified patients...
TAS-102 is a novel oral nucleoside antitumor agent that consists of trifluridine (FTD) and tipiracil hydrochloride (TPI) at a molecular ratio of 1:0.5, and was approved in Japan in March 2014 for the treatment of patients with unresectable advanced or recurrent colorectal cancer that is refractory to standard therapies. In the present study, we used colorectal cancer xenografts to assess whethe...
PURPOSE TAS-102 is a combination of the thymidine-based nucleoside analog trifluridine and the thymidine phosphorylase inhibitor tipiracil. Efficacy and safety of TAS-102 in patients with metastatic colorectal cancer (mCRC) refractory or intolerant to standard therapies were evaluated in the phase 3 RECOURSE trial. Results of RECOURSE demonstrated significant improvement in overall survival (OS...
CART (cocaine- and amphetamine-regulated transcript) peptides are novel brain neuropeptides that have been shown to have a role in the control of feeding behavior in mammals. The effects of intracereboventricular (i.c.v.) administration of two CART fragments, CART (62-76) and CART (55-102) on feeding and behavioral activity of goldfish (Carassius auratus) were examined. Both CART peptide fragme...
PURPOSE Hepatocyte growth factor (HGF/SF) and its receptor c-Met have previously been shown to be up-regulated in multiple human cancers, including glioblastoma multiforme. To better understand if AMG 102, a fully human, anti-HGF/SF-neutralizing antibody, could be incorporated into current clinical practice, AMG 102 was tested preclinically in combination with temozolomide or docetaxel to deter...
بررسی داستان هاروت و ماروت در قرآن است. رویکرد قرآن به نقل تفصیلی یا اجمالی داستانها و از جمله داستان هاروت و ماروت در کنار مواعظ و پندها، نگاهی اصلاح گرانه نسبت به تاریخ دین و دین مداران است. خداوند در آیه 102 سوره بقره با اشارتی اجمالی، داستان هاروت و ماروت را که به عصر پس از نوح بازمی گردد، بیان کرده است. در مورد ماهیّت و شخصیّت هاروت و ماروت اقوال مختلفی است از جمله اینکه آن دو فرشته یا دو پا...
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