Rosacea is a chronic inflammatory condition of the facial skin affecting the blood vessels and pilosebaceous units. Rosacea is more common in persons of northern and western European descent with a fair complexion, but it can affect skin of any color. Although symptoms may wax and wane during the short term, rosacea can progress with time. Patients usually present with complaints of flushing an...

Acne vulgaris is a common disease of the pilosebaceous unit and affects adolescents and adults. Because high-quality guidelines regarding treatment of acne in pregnancy are scarce, management of this condition can be challenging. We describe the safety profile of common therapies and outline approaches based on available evidence. Topical azelaic acid or benzoyl peroxide can be recommended as b...

Up-converting rare-earth nanophosphors (UCNPs) have great potential to revolutionize biological luminescent labels, but their use has been limited by difficulties in obtaining UCNPs that are biocompatible. To address this problem, we have developed a simple and versatile strategy for converting hydrophobic UCNPs into water-soluble and carboxylic acid-functionalized analogues by directly oxidizi...

Currently, approximately 70% of paintings in museum collections are affected by the presence metallic soaps, evidenced spherical globules visible on surface paintings. They responsible for altering paintings’ through processes such as exfoliation and cracking, or even form “skins” that appear pictorial layers. The objective this study is investigation icon from Saint Mary Monastery, Techirghiol...

Thermoplastic elastomers (TPEs) are useful in various engineering and healthcare applications. A new fully biobased polyamide TPE (PA36,9) with medium hardness is reported. The elastomer synthesized using a fatty dimer amine azelaic acid, via one-pot melt condensation polymerization. resulting shows melting temperature of 83.6 °C, (Shore A/Shore D = 90/35), large elongation at break (1220%), go...

Rosacea is a common chronic skin disorder that has significant impact on the self-esteem and quality of life of affected individuals. Currently understood as an inflammatory condition that occurs in the context of an altered innate immune response, the available topical and systemic therapies function as immunomodulators to restore cutaneous homeostasis. The goals of therapy include reduction o...

To explore potential biomarkers for amoxicillin/clavulanate-induced liver injury (AC-DILI), we conducted a clinical trial in 32 healthy subjects based on multi-omics approaches. Every subject was administered amoxicillin/clavulanate for 14 days. The liver-specific microRNA-122 (miR-122) level increased prior to and correlated well with the observed alanine aminotransferase (ALT) level increase....

Topical retinoids, benzoyl peroxide, azelaic acid, and topical and oral antibiotics remain the milestone of treatment for mild to moderate acne vulgaris. Oral isotretinoin is useful for the treatment of severe nodular acne, treatment-resistant acne, and acne with a risk of physical or psychological scarring. Hormonal treatment in female acne is useful in resistant or late-onset acne. With incre...

Background Melasma is a persistent skin condition affecting individuals of Asian, African, and Hispanic backgrounds. It causes dark patches on sun-exposed areas the face. The exact are unclear, but UV light hormonal factors play role. significantly impacts physical appearance quality life, causing emotional social distress. Objective objective was to compare efficacy combination oral tranexamic...