The 3-phenyl-2-(pyridin-2-yl)oxazolidine ligand (ppo) was synthesised and its coordination behaviour regarding Ni(II) and Pd(II) centres was studied. The reaction with K(2)PdCl(4) affords [Pd(N,N'-ppo)Cl(2)] (1), in which ppo binds to palladium via the pyridyl nitrogen and the oxazolyl nitrogen atoms. On the contrary, reaction with NiCl(2)·6H(2)O produces [Ni(N,O-ppo)(2)Cl(2)] (2), in which two...

The reactions of 2-perfluoroacyl-1H-benzo[f]chromenes and 6,7-dimethyl-3-trifluoroacetyl-4H-chromene with primary aliphatic amines ammonia afforded a series enamino ketones containing (2-hydroxynaphthalen-1-yl)methyl or 2-hydroxybenzyl substituent in the ?-position respect to carbonyl group. These involved opening pyran ring, which followed aza-Michael addition as initial step. obtained were fo...

Glutathione transferase (GST) A2-2 is the human enzyme displaying the highest catalytic activity with the prodrug azathioprine (Aza). The reaction releases pharmacologically active 6-mercaptopurine by displacing the imidazole moiety from the Aza molecule. The GST-catalyzed reaction is of medical significance, since high rates of Aza activation may lead to adverse side effects in treated patient...

A facile synthetic route to access polyfluoroalkyl functionalized cyclobutenes bearing an exo cyclic double bond from 3-aza-1,5-enynes is reported. The reaction proceeds via a thermal aza-Claisen rearrangement to give an allene-imine intermediate; subsequent cyclization affords the cyclobutene core. The kinetics of the transformation of starting material and the intermediate was studied by (1)H...

The one-pot, multi-component synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) by tandem Knoevenagel-Michael reaction of phenylhydrazine, ethyl acetoacetate and aldehydes in the presence of silica-bonded N-propylpiperazine sulfamic acid (SBPPSA) as a recyclable solid acid catalyst was reported. SBPPSA showed much the same efficiency when used in consecutive reaction runs.

The use of the solvent engineering has been applied for controlling the resolution of lipase-catalyzed synthesis of β-aminoacids via Michael addition reactions. The strategy consisted of the thermodynamic control of products at equilibrium using the lipase CalB as a catalyst. The enzymatic chemo- and enantioselective synthesis of (R)-(-)-N-benzyl-3-(benzylamino)butanamide is reported, showing t...

A Simple and efficient method for Michael addition of pyrrole and indole to α,β- un saturated compounds has been developed in the presence of oxalic acid under refluxing reaction condition was achieved.

Electron-rich aza-aromatic compounds such as indoles is structures of particular interest and importancein organic chemistry. A useful procedure for the preparation of new 3-sulfenyl indole derivatives using S-alkyl or S-arylthiophthalimides as sulfenylating agents and poly(N, N′-dibromo-N-ethyl-naphthyl-2,7-disulfonamide) as novel catalyst is described. The method represents an efficient prepa...

A series of subporphyrin-based fluorescent probes bearing 1-aza-15-crown-5 or 1-aza-18-crown-6 moieties at the meso axial positions were prepared by Pd-catalyzed Buchwald-Hartwig amination reaction corresponding bromosubporphyrins. Both types aza-crown-ether-incorporated subporphyrins in solution and exhibited cation-dependent absorption fluorescence changes. In titration experiments, opposite ...