Two studies examined the influence of approach and avoidance social goals on memory for and evaluation of ambiguous social information. Study 1 found that individual differences in avoidance social goals were associated with greater memory of negative information, negatively biased interpretation of ambiguous social cues, and a more pessimistic evaluation of social actors. Study 2 experimentall...

Introduction: Drugs of abuse such as nicotine and morphine used systemically by addicts produce their effects via the mesolimbic dopaminergic pathway. Furthermore, evidence indicates that some behavioral effects of nicotine and morphine are mediated by nitric oxide (NO). Based on these observations, the aim of the present study was to investigate the effects of intra-nucleus accumbens (NAc) ...

background several studies showed that dopamine and norepinephrine improve retention and retrieval of memory. methylphenidate is an enhancer of dopamine and norepinephrine in brain. objectives in the present study, the effect of methylphenidate was evaluated on retention and retrieval of memory in young and aged mice using passive avoidance apparatus. materials and methods animals were divided ...

Attachment avoidance has been associated with impairments in memory for material with emotional, attachment-related themes (e.g., loss). In the present study the author investigated the source and extent of these memory deficits by examining working memory capacity for attachment-related and nonattachment-related material. Avoidance was associated with deficits in working memory for positive an...

In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom body, called MVP2, or mushroom body output neuron (MBON)-γ1pedc>α/β. However, ...

Spatial navigation is used as a popular animal model of higher cognitive functions in people. The data suggest that the hippocampus is important for both storing spatial memories and for performing spatial computations necessary for navigation. Animals use multiple behavioral strategies to solve spatial tasks often using multiple memory systems. We investigated how inactivation of the rat hippo...

Our recent data have indicated that scopolamine, a non-selective muscarinic receptor antagonist, improves memory consolidation, in a passive avoidance task, tested in rats. It has been found that verapamil, a phenylalkylamine class of the L-type voltage-dependent calcium channel antagonist, inhibits [3H] N-methyl scopolamine binding to M1 muscarinic receptors. However, there are no data about t...

many factors are involved in learning and memory processes including brain nuclei, neurotransmitter systems, and the activity of ion channels. studies showed inconsistent effects of calcium channel blockers on learning process, especially memory consolidation; however, little is known about their effect on memory acquisition and retrieval. accordingly, the present study aimed to determine the e...