INTRODUCTION Immune thrombocytopenic purpura (ITP) is an autoimmune hematological disorder that causes decreased production and destruction of platelets leading to thrombocytopenia. Although thrombocytopenia usually causes hemorrhagic problems, thrombotic events like strokes, although rare, can still occur. Management of thrombotic events in patients with ITP differs from that of patients with ...

Immune thrombocytopenia occurs when antibodies targeting specific glycoproteins (GPs) on the platelet surface lead to their destruction. Tests of the patient’s platelets and serum for antibodies and typing of DNA for human platelet alloantigens (HPA) can be helpful in confirming a clinical diagnosis of immune thrombocytopenia. A thorough workup includes 1) serum tests using intact platelets; 2)...

We report a case of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura (Evans' syndrome) associated with gastric plasmacytoma. Recognition of this rare entity is important because surgery and chemotherapy together may achieve a cure. Possible mechanisms causing the hemolytic anemia and thrombocytopenia are discussed.

Circulating thrombopoietin and interleukin-6 concentrations were investigated in two different settings of thrombocytopenia. Twenty patients with autoimmune thrombocytopenic purpura (ATP), 12 patients with aplastic anemia (AA) and 15 healthy subjects were studied. Thrombopoietin was significantly increased in AA and deficient in ATP. Interleukin-6 was significantly increased in ATP, compared to...

Immune thrombocytopenia (ITP), previously called idiopathic thrombocytopenia purpura, is an autoimmune disorder characterized by a severe reduction in peripheral blood platelet count. In healthy individuals, normal platelet count ranges from 150-450 × 109/L, while in thrombocytopenia counts fall to less than 100 × 109/L.1 In adults, the incidence of ITP is approximately two to four per 100,000....

Platelets are anuclear blood cells whose function is to form blood clots when we injure ourselves, to prevent excessive blood loss. Thrombocytopenia is a relative low number of platelets in the blood. Thrombocytopenia has several possible causes, including the trapping of platelets in spleen, reduced production of platelets and increased breakdown of platelets. Some examples of an increase in p...

Immune Thrombocytopenia (ITP) is an autoimmune disorder characterised by a low platelet countless than 100? ×? 10^9/L, purpura, and hemorrhagic episodes induced antiplatelet autoantibodies without anemia or leukopenia. thrombocytopenia occurs in 2 to 4/100? 000 adults. A wide range of signs symptoms, from modest mucocutaneous petechiae severe, life-threatening organ haemorrhage, are seen ITP pa...

This case report describes the simultaneous occurrence of autoimmune thrombocytopenia and the lupus anticoagulant in a patient with primary adenocarcinoma of the bronchus. Treatment with corticosteroids and plasmapheresis resulted in a return to normal of the partial thromboplastin time and the disappearance of the platelet antibodies. The carcinoma was inoperable.

Interspecies platelet immunizations among marmosets lead to antibody formation to the donor platelets and a profound thrombocytopenia, which when associated with anemia may result in death of the animal. This actively induced immunologic thrombocytopenia closely resembles two clinical disease entities manifesting autoimmune thrombocytopenia, posttransfusion purpura and idiopathic thrombocytopen...