background this prospective study was designed to examine the role of fibrosis staging on selection and success of treatment options for autoimmune hepatitis (aih). materials and methods the project was conducted on 110 selected aih patients who, based on the results of liver biopsy, had been assigned into one of the three groups (mild, stages 1 and 2, moderate, stages 3 and 4, and severe, stag...

Waldenström first described the disease entity now termed autoimmune hepatitis (AIH) in 1950, when he observed a chronic form of hepatitis in young women.1 This hepatitis led to cirrhosis and was associated with jaundice, elevated gamma globulins, and amenorrhea.2 The disease was found to be associated with other autoimmune syndromes3 and was later termed “lupoid hepatitis” because of the prese...

IgG4-related disease (IgG4-RD) is a rare condition characterized by an immune-mediated fibro-inflammation affecting various organs (liver, pancreas, heart, kidney, brain among others) with peculiar histopathologic feature. Few epidemiological data have been published so far, although dramatic increase in the number of patients diagnosed IgG4-RD has recorded last years. The clinical manifestatio...

INTRODUCTION There are reports suggesting that hepatitis C virus (HCV) may stimulate the autoimmune process. Studies have been undertaken to evaluate the occurrence and type of autoantibodies in HCV-infected patients with and without immunosuppression. Results were analyzed according to HCV genotype, intensity of inflammation and liver fibrosis stage. MATERIAL AND METHODS The study included 1...

conclusions with our laboratory diagnostic method, it seems that there are no cases of oci in patients with aih. however, we recommend further studies with more samples and more precise laboratory method. results six males and 29 females with mean disease duration of 77.1 ± 39.5 month and mean age of 43.62 ± 12.67 years were investigated. all cases were negative for anti-hcv antibody and we cou...

Autoimmune hepatitis is defined as chronic liver disease of unknown aetiology with aberrant auto-reactivity and genetic predisposition, characterized by female predominance, circulating auto-antibodies, hypergammaglobulinemia and association with HLA DR3 and HLA DR4. We present two patients with autoimmune hepatitis. The first patient is a young lady who was diagnosed with autoimmune chronic he...

A case is reported of a 29 year old female who had autoimmune hepatitis associated with mixed connective tissue disease (MCTD). The patient developed MCTD at the age of 19, and was treated with prednisolone. Liver dysfunction developed 7 years later, which exacerbated shortly after the patient suffered intrauterine fetal death during the second trimester of pregnancy. Laboratory data showed neg...

aim : the aim of this study was to review our experience with gestations in autoimmune hepatitis patients. background : there are only limited data describing pregnancy in patients with autoimmune hepatitis. patients and methods : retrospective analysis of pregnancies with autoimmune hepatitis followed in centro hospitalar do porto, portugal in the last ten years. results : we reported nine pre...