Introduction Auto-inflammatory syndromes are defined as conditions caused by an exaggerated innate immune system response, resulting in episodes of spontaneous inflammation affecting multiple organs. The prototypical auto-inflammatory disorders are associated with periodic febrile episodes. Auto-inflammatory syndromes now include polygenic diseases, such as Behcet’s syndrome and Still’s disease...

In this study, local neuronal interactions in the midbrain dorsal raphe nucleus (DRN) were analyzed by the use of autocorrelation and cross-correlation histograms. The autocorrelograms of serotonin (5-hydroxytryptamine; 5-HT)-containing cells showed an initial trough and subsequent periodicity which corresponded to their regular rhythmic firing pattern. Cross-correlograms revealed that all adja...

DEPTOR is a recently identified inhibitor of the mTOR kinase that is highly regulated at the posttranslational level. In response to mitogens, we found that DEPTOR was rapidly phosphorylated on three serines in a conserved degron, facilitating binding and ubiquitylation by the F box protein βTrCP, with consequent proteasomal degradation of DEPTOR. Phosphorylation of the βTrCP degron in DEPTOR i...

As many as 59% of the transcription factors in Escherichia coli regulate the transcription rate of their own genes. This suggests that auto-regulation has one or more important functions. Here, one possible function is studied. Often the transcription rate of an auto-regulator is also controlled by additional transcription factors. In these cases, the way the expression of the auto-regulator re...

All living organisms depend on dynamic mechanisms that repeatedly reassess the status of amassed energy, in order to adapt energy supply to demand. The AMP-activated protein kinase (AMPK) alphabetagamma heterotrimer has emerged as an important integrator of signals managing energy balance. Control of AMPK activity involves allosteric AMP and ATP regulation, auto-inhibitory features and phosphor...

We report a study that examines performance of pilots flying a simulated UAV in a highfidelity environment while using different types of perfect and imperfect automation aids. Fiftysix student pilots carried out simulated UAV missions containing a 3D view of terrain, a 2D topdown navigational map, system parameter gauges, and a message box. Trajectory and manipulation of a 3D camera was contro...

Abstract: In this paper, conditions of the chaos in auto gauge control system are suggested and proved on the basis of the roll eccentricity model. It is proposed that the eccentricity disturbance of roll may cause chaotic phenomena in the rolling process. By analyzing four kinds of expandable and shrinkable factors of variable universe fuzzy controller, it is suggested that the contradiction b...