www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 1667 Definition Autistic disorder is a pervasive developmental disorder defined behaviorally as a syndrome consisting of abnormal development of social skills (withdrawal, lack of interest in peers), limitations in the use of interactive language (speech as well as nonverbal communication), and sensorimotor deficits (inconsistent responses to environme...

BACKGROUND Autism spectrum disorders (ASDs) are persistent disabling neurodevelopmental disorders clinically evident from early childhood. For the first time, the burden of ASDs has been estimated for the Global Burden of Disease Study 2010 (GBD 2010). The aims of this study were to develop global and regional prevalence models and estimate the global burden of disease of ASDs. METHOD A syste...

BACKGROUND Autistic spectrum disorders are a group of neurological and developmental disorders associated with social, communication, sensory, behavioral and cognitive impairments, as well as restricted, repetitive patterns of behavior, activities, or interests.The aim of this study was a) to analyze QEEG findings of autistic patients and to compare the results with data base; and b) to introdu...

BACKGROUND language and communication disorders are proposed as one of the three fundamental criteria for the description or diagnosis of pervasive developmental disorders (PDD), along with social disabilities and a narrow focus of interest. This way, the determination of simple procedures that can be used by health and education professionals to identify the persons that need specialized servi...

In accordance with the developmental theories, the formation of gender identity is subject to an interactive logic in which biology, social coexistence and culture are considered as an inseparable unit. When studying clinical conditions of multifactorial origin and with specific characteristics it has become essential consider the impact the formation of gender identity, mainly when maintains a...

Recent studies of perceptual adaptation to faces have revolutionised our understanding of neural mechanisms that support face recognition. A new study has applied this approach to autistic spectrum disorders, revealing severe deficits in such adaptation.

It is common to administer measures of autistic traits to those without autism spectrum disorders (ASDs) with, for example, the aim of understanding autistic personality characteristics in non-autistic individuals. Little research has examined the extent to which measures of autistic traits actually measure the same traits in the same way across those with and without an ASD. We addressed this ...

BACKGROUND Autism spectrum disorders (ASDs) are neurodevelopmental conditions characterized by social and behavioural impairments. In addition to neurological symptoms, ASD subjects frequently suffer from gastrointestinal abnormalities, thus implying a role of the gut microbiota in ASD gastrointestinal pathophysiology. RESULTS Here, we characterized the bacterial and fungal gut microbiota in ...

To address a possible environmental contribution to autism, we carried out a retrospective study on urinary porphyrin levels, a biomarker of environmental toxicity, in 269 children with neurodevelopmental and related disorders referred to a Paris clinic (2002-2004), including 106 with autistic disorder. Urinary porphyrin levels determined by high-performance liquid chromatography were compared ...

The prevalence of MHL in 202, 1 to 6 year-old children with communication disorders who visited our clinic in 1991 was investigated. 1) 31% of the subjects had MHL bilaterally. The prevalence of MHL was 44% at age 1 year, 20% at age 2 years, 36% at age 3 years, 24% at age 4 years, 39% at age 5 years, 33% at age 6 years. 2) 88% of children with MHL had OME, 10% had mild sensorineural hearing los...