نتایج جستجو برای: atypical scid

تعداد نتایج: 54097  

Journal: :Blood 1995
Y Heike T Ohira M Takahashi N Saijo

An attempt was made to establish an SCID-hu murine model of long-term human hematopoiesis by coimplantation of a bone fragment and bone marrow (BM) cells from an adult human. The SCID-hu mice were treated with a cytokine mixture (recombinant human stem cell factor, interleukin-3, granulocyte/macrophage colony-stimulating factor, and granulocyte colony-stimulating factor) for 4 months and were t...

2017
Gregory S Chasson Monnica T Williams Darlene M Davis Jessica Y Combs

BACKGROUND Research on the utility of structured interviews in assessing OCD is scarce, and even more so, in its use for OCD in African Americans. The purpose of this study was to examine the utility of the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) in detecting OCD in African Americans when used by well-trained, culturally competent clinicians. METHODS Seventy-four Af...

Journal: :Frontiers in bioscience : a journal and virtual library 2005
Hai Huang Kenneth G Manton

Because prompt intervention may prevent complications, early diagnosis is important in many inherited metabolic diseases. Early diagnosis of Severe Combined Immunodeficiency (SCID) is critical - because chances for successful treatment are highest for infants who have not yet experienced severe opportunistic infections. SCID is a rare disease that can be detected in newborn infants (i.e., those...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1992
J B Sacci M E Schriefer J H Resau R A Wirtz L J Detolla R B Markham A F Azad

Research on the exoerythrocytic (EE) stages of human malaria parasites has been hindered because of the lack of an easily available suitable animal model. We report here an approach to produce mature EE-stage Plasmodium falciparum parasites by using severe combined immunodeficient (scid) mice with transplanted human hepatocytes. Transplantation of human hepatocytes into scid mice (scid hu-hep),...

2003
Gaurav Chakravorty Paritosh K. Pandya

Interval Duration Logic, (IDL), is a dense time logic for specifying properties of real-time systems. Its validity is undecidable. A corresponding discrete-time logic QDDC has decidable validity. In this paper, we consider a reduction of IDL validity question to QDDC validity using notions of digitization. A new notion of Strong Closure under Inverse Digitization, SCID, is proposed. It is shown...

Ali Akbar Moghadamnia, Ebrahim Zabihi, Mahmoud Baradaran, Meisam Shabanzadeh, Sina Arabsheibani,

Background: Pseudocholinesterase (PChE) polymorphism has been a subject of several pharmacogenetic studies worldwide. The patients with atypical homozygous genotype do not only have reduced serum cholinesterase activities but also their elimination rate for some pharmacologically potent drugs decrease drastically. This study was designed to evaluate the PChE polymorphism in Mazandaran province ...

Journal: :Blood 1993
F M Uckun J R Downing R Gunther L M Chelstrom D Finnegan V J Land M J Borowitz A J Carroll W M Crist

Severe combined immunodeficient (SCID) mice were injected intravenously with 5 x 10(6) primary bone marrow (BM) blasts from newly diagnosed patients with E2A-PBX1 fusion transcript positive t(1;19)(q23;p13) pre-B acute lymphoblastic leukemia (ALL). A marked variation existed in the pattern and extent of leukemic cell engraftment in SCID mice challenged with t(1;19) pre-B ALL blasts. Blasts from...

Journal: :Cancer research 1996
M Korbelik G Krosl J Krosl G J Dougherty

Photodynamic therapy (PDT) treatment of murine EMT6 mammary sarcoma using Photofrin (10 mg/kg) and light (110 J/cm2) cured all these lesions growing in syngeneic BALB/c mice. In contrast, the same treatment produced initial ablation but no long-term cures of EMT6 tumors growing in either scid or nude mice, the immunodeficient strains sharing the same genetic background with BALB/c mice. No diff...

Abbasi S Honaramooz A

Background: The aim of the present study was to examine factors that may affect the outcome of testis tissue xenografting. Recipient factors were examined by grafting small fragments of testis tissue from newborn piglets under the back skin of immunodeficient mice of different strains [severe combined immunodeficiency (SCID) vs. nude), sex (male vs. female) and gonadal status (intact vs. gonade...

Journal: :Circulation research 1994
P L Schwimmbeck C Badorff H P Schultheiss B E Strauer

Severe combined immunodeficiency (SCID) mice possess neither T nor B lymphocytes and are thus suitable recipients for lymphocytes of different species. Because autoimmune mechanisms are suspected in the pathogenesis of myocarditis (MC), we attempted to determine whether peripheral blood lymphocytes (PBLs) from patients with MC could be transferred into SCID mice and whether they had an autoimmu...

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