Synchronous ovarian and uterine cervix malignancies are extremely rare gynecologic neoplasia. In the meantime the presence of hepatic metastases originating from cervical cancer is another rare situation, the liver being more often a common site of metastases for ovarian malignancies. We present the case of a 63-year-old patient who was diagnosed with a moderately differentiated squamous cell c...

Introduction: In Japan, there is free physical checkup programs of cancer screening, by which asymptomatic participants undergo a medical examination at public expense. The present study aims to describe their gynecologic findings and compare them with the literatures reported from general hospitals and selfpaid check-up programs. Methods: Medical records of Japanese women, who underwent gyneco...

The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. We have previously reported that AGER was overexpressed in squamous cervical cancer. However, mechanisms of AGER involved in the progression of cervical cancer are unknown. In the present study, we investigated the effects of AGER on biological behavior, includ...

BACKGROUND Little is known regarding the human papillomaviruses (HPV) genotypes prevalent in women in South Africa, a country with a high incidence of cervical cancer. OBJECTIVE To determine the prevalence and HPV genotypes in women with squamous abnormalities and normal cervixes participating in a community-based microbicide study. STUDY DESIGN A total of 159 cervical specimens, including ...

BACKGROUND Persistent infection with high-risk human papillomavirus (HPV) has been recognized as a major cause of cervical cancer. Distribution of HPV genotypes may differ according to the geographic region and the severity of the cervical lesion. Determining HPV genotypes' specific distribution is useful for HPV surveillance and control programs. However, little is known about the distribution...

background and objective: the aim of this study was to compare the screening performance of a new modified liquid-based cytology method (liquiprep™) with conventional pap smear (cp) in a low risk population, using colposcopy followed by histology as “gold standard”. patients and methods:  this cross-sectional study was performed on random referred specimens to a general gynecological clinic in ...

The aim of this study was to compare the diagnostic efficacy colposcopic-directed biopsy and four-quadrant in detecting high-grade cervical intra-epithelial neoplasia (CIN). Women attending three women’s clinics for routine screening were recruited. Colposcopy arranged women with any cytologic abnormalities greater than atypical squamous cells undetermined significance (ASCUS), two consecutive ...

Background In South Africa, cervical cancer remains among the most common cancers and a leading cause of cancer death. Co-infection with HIV increases the risk of developing cervical pre-cancer and cancer. We analysed National Health Laboratory Service cervical cytology data to investigate geographic variations of Pap smear coverage, quality, and high grade lesions. Methods Facility-level dat...

BACKGROUND The prevalence and genotype distribution of Human papillomavirus (HPV) infection vary depending on geographical region and the immunity provided by vaccines. This study aimed to clarify the recent prevalence and genotype distribution of HPV according to age and cervical cytology findings in Korea. METHODS This study included 18,815 health examinees that underwent cervical cytology ...