Ovarian failure is related to dyslipidemias and inflammation, as well as to hypertrophy and dysfunction of the visceral adipose tissue (VAT). Although hypothyroidism has been associated with obesity, dyslipidemias, and inflammation in humans and animals, its influence on the characteristics of ovarian follicles in adulthood is scarcely known. Control and hypothyroid rabbits were used to analyze...

High-producing dairy cows are subfertile; however, the mechanisms responsible for the decreased fertility are unknown. The aim of the present study was to test the hypothesis that culled dairy cows (4-8 years old) characterised by 'Lo' ovaries (i.e. those with <10 mid-antral follicles) are affected by premature ovarian senescence. Cows in which both ovaries were 'Lo' ovaries represented 5% of t...

The objective of the present study was to characterize changes in growth, concentrations of steroids in follicular fluid (FF) and gonadot ropin receptors of individual antral follicles after spontaneous luteolysis in heifers and to reexamine our hormonal method of classifying healthy and atretic follicles. Groups of heifers were ovariectomized (OVX) before regression of corpora lutea on d 17, 1...

background: bisphenol a (bpa), an environmental pollutant, can generate free radicals which damages the reproductive system. vitamin c is an antioxidant which may prevent the adverse effects of free radicals.objective: the aim was to investigate the effect of vitamin c on the ovary tissue in rats treated with bpa.materials and methods: in this experimental study, 24 female wistar rats (200±20 g...

Introduction: Cyclophosphamide is one of the alkylating chemotherapeutic drug used in cancer patients that has antifertility effects on female gonads. Ocimum basilicum a natural herb rich polyphenols and known to improve fertility. Aims &amp; Objectives: The study was designed evaluate role herb, extract, as preventive agent against ovarian follicular toxicity induced by cyclophosphamide. Place...

BACKGROUND Dominant follicle selection is disturbed in normogonadotrophic anovulatory infertility [World Health Organization (WHO) 2] and remaining early antral follicles are either healthy or atretic. This study was conducted to investigate whether inhibin B serum concentrations (produced by healthy small antral follicles) represent the extent of ovarian abnormalities in WHO 2 women and patien...

Mammalian ovary development undergoes important changes during the perinatal period, moment when follicles are assembled and start to develop in a process not well known, involving endocrine and paracrine factors. In order to investigate the effect of two different hormonal environments on the early development of the ovary, we used an autologous transplant model in which Syrian hamster fetal o...