نتایج جستجو برای: atovaquone
تعداد نتایج: 456 فیلتر نتایج به سال:
To the Editor—A 57-year-old woman from Cape Cod presented to our facility with fever and a syncopal episode. She reported 1 week of fatigue before her evaluation. On examination, she was febrile (38.6 C) but otherwise appeared well, with a positive Castell’s sign and palpable spleen tip. Her medical history was significant for Crohn’s disease treated with infliximab, with the most recent dose a...
US military physicians and researchers helped identify the optimum treatment dose of the naturally occurring compound quinine and collaborated with the pharmaceutical industry in the development and eventual US Food and Drug Administration approval of the synthetic antimalarial drugs chloroquine, primaquine, chloroquine-primaquine, sulfadoxine-pyrimethamine, mefloquine, doxycycline, halofantrin...
The prevalence of a genetic polymorphism(s) at codon 268 in the cytochrome b gene, which is associated with failure of atovaquone-proguanil treatment, was analyzed in 227 Plasmodium falciparum parasites from western Kenya. The prevalence of the wild-type allele was 63%, and that of the Y268S (denoting a Y-to-S change at position 268) mutant allele was 2%. There were no pure Y268C or Y268N mutan...
BACKGROUND A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum malaria with prolonged activity would substantially advance malaria control. DSM265 is an experimental antimalarial that selectively inhibits the parasite dihydroorotate dehydrogenase. DSM265 shows in vitro activity against liver and blood stages of P falciparum. We assessed the prophylactic activity of DSM...
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