Selective C-formyl-ation of 8,9,10,11-tetra-hydro-pyrido[2',3':4,5]pyrimido[1,2-a]-azepin-5(7H)-one has been studied for the first time. It was revealed that formyl-ation proceeds by the formation of an inter-mediate salt, which due to the re-amination process on treatment with aqueous ammonia transformed into the corresponding (E)-11-(amino-methyl-ene)-8,9,10,11-tetra-hydro-pyrido[2',3':4,5]-p...

We introduce the motivation for in ation as an additional phase of the early universe and then discuss some of the ways in which its theoretical grounding is being approached from the point of view of stringy cosmology, and, speci cally, its low-energy regime supergravity. F-term and D-term models are discussed and some limits on the admissible potentials are derived. A supergravity no-go theor...

A m ethod is described for the estim ation, by furfural form ation, of small am ounts of ribosenucleic acid (RNA) in the presence of large am ounts of deoxyribosenucleic acid. Evidence is produced to show th a t the Schm idt & T hannhauser m ethod does no t give a satisfactory separation of the two types of nucleic acids. The m ethod has been applied to the estim ation of the R N A conten t of ...

DNA repair and aging are two phenomena closely connected to each other. The poly(ADP-ribosyl)ation reaction has been implicated in both of them. Poly(ADP-ribose) was originally discovered as an enzymatic reaction product after DNA damage. Soon it became evident that it is necessary for regulation of different repair pathways. Also, evidence accumulated that poly(ADP-ribose) formation capacity i...

The WD40-repeat protein DDB2 is essential for efficient recognition and subsequent removal of ultraviolet (UV)-induced DNA lesions by nucleotide excision repair (NER). However, how DDB2 promotes NER in chromatin is poorly understood. Here, we identify poly(ADP-ribose) polymerase 1 (PARP1) as a novel DDB2-associated factor. We demonstrate that DDB2 facilitated poly(ADP-ribosyl)ation of UV-damage...

ABSTRACT In this paper we des ribe a ooperative negotiation proto ol that solves a distributed resour e allo ation problem while onforming to soft-real time onstraints in a dynami environment. By framing the allo ation problem in terms of optimization, we have been able to develop a number of te hniques to address an ever hanging problem lands ape. Amongst these te hniques are the ability to re...

It has been argued that rising dowry payments are caused by population growth. According to that explanation, termed the `marriage squeeze', a population increase leads to an excess supply of brides since men marry younger women. As a result, dowry payments rise in order to clear the marriage market. The explanation is essentially static; unmarried brides do not re-enter the marriage market. Th...

We develop a global vector autoregressive model GVAR to analyze macroeconomic shock transmission among the East African Community countries. The results suggest that there is a signi…cant growth and in‡ation shock transmissions from Kenya to the rest of the member countries while the transmission in the opposite direction is insigni…cant. The macroeconomic shocks are re‡ected more on prices tha...

Interest in the measurement of infl ation has increased signifi cantly in recent years for a number of reasons. First, infl ation rates have fallen signifi cantly since the early 1980s. Second, many central banks have adopted infl ation targets. The combination of these two factors has increased the importance of accurate measurement. Third, rapid quality improvements, particularly in the infor...

In these lectures, I review the standard hot Big Bang cosmology, emphasizing its successes, its shortcomings, and its major challenges|developing a detailed understanding of the formation of structure in the universe and identifying the constituents of the ubiquitous dark matter. I then discuss the motivations for|and the fundamentals of|in ationary cosmology, particularly emphasizing the quant...