Reproducible left ventricular dimensions were found by M-mode echocardiography in eight healthy men in the semisupine position during two maximal bicycle exercise tests, performed with four hours interval. Left ventricular end-diastolic dimension did not increase during maximal exercise, while fractional shortening increased by a decrease in end-systolic dimension. Twelve men studied by the sam...

Essential hypertension is often accompanied by abnormalities of the coagulation/fibrinolytic system, predisposing to a procoagulant state. The aim of the present study was to compare the effects of atenolol (beta1-blocker agent) and irbesartan (angiotensin II type 1 receptor antagonist) on plasma levels of hemostatic/fibrinolytic and endothelial function markers in a cohort of previously untrea...

OBJECTIVES The goal of this study was to determine if a low-dose combination of the angiotensin-converting enzyme inhibitor perindopril (Per) and the diuretic indapamide (Ind) reduces central (thoracic aorta, carotid artery) as well as brachial systolic blood pressure (SBP) more than the beta-blocker atenolol and to determine the hemodynamic factors influencing independently brachial and centra...

An increasing body of evidence suggests that cytokines may play a role in the pathogenesis of cardiovascular diseases. Immunopharmacological studies provide new information on immunomodulating activity of some drugs, including their effect on the level of pro-inflammatory cytokines. The aim of the present study was to find out whether amlodipine and atenolol, drugs applied in the treatment of a...

Abstract Using the starting reactants of Zn(OAc) 2 and 2-mercaptonicotinic acid (H L), we successfully synthesized a fresh Zn( ii ) compound, that is, [Zn 3 (L) ] n (1), under hydrothermal conditions then loaded with atenolol. Hualuronic acid/carboxymethyl chitosan hydrogels atenolol drug metal–organic framework were prepared based on chemical synthesis method. The microscopic morphology was in...

Abstract: Aim: Hypertension exhibits a circadian rhythm and drugs need to be released at the time when blood pressure is elevated most. This elevation pronounced 7 pm 4 am. Atenolol an anti-hypertensive drug with absorption window mainly in upper section of gastrointestinal tract. The present investigation was aimed designing floating pulsatile capsules for dual release atenolol stomach effecti...

To assess the contribution of cardiac f2-receptors in the cardiac inotropic and chronotropic responses to a A3 agonist, terbutaline was infused (0.2 and 0.4 ,ug/kg/min), alone or after pretreatment with either oral atenolol 50 mg or atropine 0.04 mg/kg i.v. or both in six healthy subjects with a multiple crossover design. Terbutaline 0.2 ,g/kg/min increased heart rate by 15±2 beats/min, and thi...

INTRODUCTION Activation of the sympathetic nervous system has beneficial cardiovascular effects in sepsis, but there is also evidence that sympatholytics have beneficial actions in sepsis. We therefore determined the effect of selective β1-adrenoceptor blockade on cardiac and renal function and cytokine release in ovine hyperdynamic sepsis. METHODS Hyperdynamic sepsis was induced by infusion ...

Antihypertensive drugs are among the most commonly prescribed drugs for chronic disease worldwide. The response to antihypertensive drugs varies substantially between individuals and important factors such as race that contribute to this heterogeneity are poorly understood. In this study we use metabolomics, a global biochemical approach to investigate biochemical changes induced by the beta-ad...

BACKGROUND beta-Blockers and ACE inhibitors reduce early mortality when either one is started in the first hours after myocardial infarction (MI). Considering the close correlation between morphological changes and prognosis, we aimed to investigate whether the benefit of both beta-blockers and ACE inhibitors might reside in a similar protective effect on infarct size or ventricular volume. M...