OBJECTIVES To investigate the extent to which pharmacoepidemiologic groupings are homogeneous in terms of clinical properties. METHODS In our analysis, we classified drug subgroups from the pharmacoepidemiologic Anatomical Therapeutic Chemical (ATC) classification system based on clinical drug properties. We established mappings from ATC fifth level drug entities to drug property annotations ...

Improving of ATC is an important issue in the current de-regulated environment of power systems. The Available Transfer Capability (ATC) of a transmission network is the unutilized transfer capabilities of a transmission network for the transfer of power for further commercial activity, over and above already committed usage. Power transactions between a specific seller bus/area and a buyer bus...

Dissociation-induced apoptosis of human embryonic stem cells (hESCs) hampers their large-scale culture. Herein we leveraged the mechanosensitivity of hESCs and employed, to our knowledge, a novel technique, acoustic tweezing cytometry (ATC), for subcellular mechanical stimulation of disassociated single hESCs to improve their survival. By acoustically actuating integrin-bound microbubbles (MBs)...

Analytical target cascading (ATC) is a methodology for translating system-level design targets to subsystem and component design specifications in hierarchically decomposed optimal system design problems. In previous work we extended the ATC formulation to account for uncertainties, where the bounds of the probabilistic design constraints were chosen arbitrarily and held fixed during the ATC pr...

Wind energy penetration in power system has been increased very fast and large amount of capitals invested for wind farms all around the world. Meanwhile, in power systems with wind turbine generators (WTGs), the value of Available transfer capability (ATC) is influenced by the probabilistic nature of the wind power. The Mont Carlo Simulation (MCS) is the most common method to model the uncerta...

Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies, with no effective treatment currently available. Previously, we identified agents active against ATC cells, both in vitro and in vivo, using quantitative high-throughput screening of 3282 clinically approved drugs and small molecules. Here, we report that combining two of these active agents, carfilzomib, a second...

The aim of this study was to gain better insight into molecular changes which reflect disturbances in the balance between proliferation and apoptosis during progression of thyroid malignancy from papillary microcarcinoma (PMC) via clinically manifest papillary carcinoma (PTC) to anaplastic carcinoma (ATC). The apoptosis related molecules (Bcl-2, Bax) and proliferation related marker (PCNA) were...

Anaplastic thyroid cancer (ATC) is among the most lethal types of cancers, characterized as a fast-growing and highly invasive thyroid tumor that is unresponsive to surgery and radioiodine, blunting therapeutic efficacy. Classically, genetic alterations in tumor suppressor TP53 are frequent, and cumulative alterations in different signaling pathways, such as MAPK and PI3K, are detected in ATC. ...

Here, we show that the anaplastic thyroid carcinoma (ATC) features the up-regulation of a set of genes involved in the control of cell cycle progression and chromosome segregation. This phenotype differentiates ATC from normal tissue and from well-differentiated papillary thyroid carcinoma. Transcriptional promoters of the ATC up-regulated genes are characterized by a modular organization featu...