In mice, generation of autoreactive CD5+ B cells occurs as a consequence of BCR signaling induced by (self)-ligand exposure from fetal/neonatal B-1 B cell development. A fraction of these cells self-renew and persist as a minor B1 B cell subset throughout life. Here, we show that transfer of early generated B1 B cells from Eμ-TCL1 transgenic mice resulted in chronic lymphocytic leukemia (CLL) w...

A C K N O W L E D G M E N T S ........................................................................................... vi 1 In tro d u ctio n ... 1 2 Parallel P rocessin g ............................................................................. 3 2.1 Parallel C o m p u te rs ................................... 3 2.2 Parallel C o m p u ta tio n s ............................................

Mulkey, Daniel K., Richard A. Henderson III, Robert W. Putnam, and Jay B. Dean. Pressure ( 4 ATA) increases membrane conductance and firing rate in the rat solitary complex. J Appl Physiol 95: 922–930, 2003. First published April 18, 2003; 10.1152/japplphysiol.00865. 2002.—Neuronal sensitivity to pressure, barosensitivity, is illustrated by high-pressure nervous syndrome, which manifests as inc...

The neuroprotective effect of oxygen after acute stroke in rats has been shown previously. However, the question of optimal dosing still remains unanswered. Thus, we investigated the use of oxygen at different concentrations by either normobaric oxygenation (NBO) or hyperbaric oxygenation (HBO) at different pressures in a model of transient ischemia/reperfusion in rats. Animals underwent 90 min...

AIMS The aim of this study was to elucidate the effects of regulator of G-protein signaling 5 (Rgs5), a negative regulator of G protein-mediated signaling, on atrial repolarization and tachyarrhythmia (ATA) in mice. METHODS AND RESULTS In present study, the incidence of ATA were increased in Rgs5(-/-) Langendorff-perfused mouse hearts during program electrical stimulation (PES) (46.7%, 7 of 1...

We developed a hyperbaric chamber for intracellular recording in rat brain stem slices during continuous compression and decompression of the tissue bath with the inert gas helium. Air, rather than helium, was also used as the compression medium in some cases to increase tissue nitrogen levels. An important feature is the chamber door, which opens or closes rapidly at 1 atmosphere absolute (ATA...

BACKGROUND T wave alternans (TA) is a repolarisation phenomenon manifesting as a microvolt beat to beat change in the amplitude of the T wave and ST segment. TA has been shown to be a predictor of arrhythmic risk in unselected myocardial infarction populations. TA has not been used to differentiate risk within the ischaemic cardiomyopathy population. METHODS The subjects investigated comprise...

In this paper, we introduce new definitions of L-fuzzy neighborhood systems, L-fuzzy interior operators and L-fuzzy closure operators. Three characterizations of the category L-FTOP of L-fuzzy topological spaces and their L-fuzzy continuous mappings are presented by means of the category L-FNS of L-fuzzy neighborhood spaces and their continuous mappings, the category L-FIS of L-fuzzy interior s...

As a new generation radio telescope, the Allen Telescope Array (ATA) is a prototype for the SKA. Here we describe recently developed design constraints for the ATA digital signal processing chain as a case study for SKA processing. As radio frequency interference (RFI) becomes increasingly problematical for radio astronomy, radio telescopes must support a wide range of RFI mitigation strategies...