BACKGROUND CD27, a lymphocyte specific member of the Tumour Necrosis Factor- Receptor (TNF-R) family is expressed on the majority of peripheral blood T cells. Activation of T cells via TCR/CD3 induces high CD27 surface expression and release of a soluble form (sCD27) of the molecule. sCD27 level increases in patients suffering from a variety of chronic inflammatory diseases. In the present stud...

OBJECTIVE To investigate the association of Arg16Gly and Gln27Glu polymorphisms of β2-adrenergic receptor gene (ADRB2) with the occurrence of asthma and overweight and the gene's influence on anthropometric, clinic, biochemical and physical fitness variables in children and adolescents. METHODS Subjects were evaluated for allelic frequencies of the β2-adrenergic receptor gene, height, weight,...

Neck accessory respiratory muscles and mouth breathing suggest a direct relationship among asthma, Temporomandibular (TMD) and Cervical Spine (CSD) Disorders. This study was performed to evaluate and correlate TMD, CSD in asthmatic and non-asthmatic. Thirty asthmatic children (7.1 +/- 2.6 years old), 30 non-asthmatic predominantly mouth breathing children (Mouth Breathing Group - MBG) (8.80 +/-...

background the purpose of this study was to examine the relationship between the type of inhaled medication, length of use, dosing, the inhaler use technique and the severity and duration of disease on the dental caries of asthmatic patients. objectives in the present study, the frequency of dental caries in the asthmatic patients and control group was examined. in addition the possible associa...

abstract: introduction: asthma is a common disorder that affects children. only a limited number of studies have investigated the effect of asthma on dental caries. the purpose of this study was to determine the dental caries status in children with bronchial asthma. methods and materials: in this crossectional study, 75 asthmatic and 75 non asthmatic children who were matched according to age ...

OBJECTIVES Much scientific evidence indicates a positive association between moldy environments and respiratory illnesses and/or symptoms (e.g., asthma). Recently, submicron fungal fragments (<1.0 μm) have been suggested as a potential contributor to adverse health effects due to their biological composition (e.g., antigens, mycotoxins, and (1,3)-β-D-glucan) as well as their small size. However...

asthma is considered to be the most common respiratory disorder complicating pregnancy. seventy-six asthmatic and 152 non-asthmatic pregnant women were studied. maternal asthma was significantly associated with adverse infant outcomes, including prematurity, low birth weight and the need for cesarean delivery. the results of this study could indicate that pregnant women with asthma were at subs...

We determined the dose-response curves to inhaled methacholine (MCh) in 16 asthmatic and 8 healthy subjects with prohibition of deep inhalations (DIs) and with 5 DIs taken after each MCh dose. Flow was measured on partial expiratory flow-volume curves at an absolute lung volume (plethysmographically determined) equal to 25% of control forced vital capacity (FVC). Airway inflammation was assesse...

Receptor affinity and drug delivery to the receptor sites could be determinant factors for the increased bronchial responsiveness seen in asthma. Competitive antagonism blockade which is measured as dose ratio-l (DR-I) depends only on these two factors. Therefore, in this study we have examined histamine HI blockade by chlorpheniramine on isolated tracheal chains of asthmatic compared to co...