Meiotic maturation is essential for the reproduction procedure of many animals. During this process an oocyte produces a large egg cell and tiny polar bodies by highly asymmetric division. In this study, to fully understand the sophisticated spatiotemporal regulation of accurate oocyte meiotic division, we focused on the global and local changes in the tension at the surface of the starfish (As...

Starfish oocytes arrest at metaphase of the first meiotic division (MI arrest) in the ovary and resume meiosis after spawning into seawater. MI arrest is maintained by lower intracellular pH (pH(i)) and release from arrest by cellular alkalization. To elucidate pH(i) regulation in oocytes, we cloned the starfish (Asterina pectinifera) Na(+)/H(+) exchanger 3 (ApNHE3) expressed in the plasma memb...

I mmune cell recruitment is a crucial process in cell homing and vertebrate immunity, initiating powerful host innate and adaptive defense mechanisms. However, immune cell recruitment also critically contributes to the pathologic sequelae of events driving various inflammatory diseases in humans such as atherosclerosis. The recruitment process is executed by chemokines, which promote the direct...

In the starfish Marthasterias glacialis, polyethylene glycol (PEG) homologous fused pairs consisting of two immature oocytes, blocked at the germinal vesicle stage, or two ootids, blocked at the female pronucleus stage, remain arrested at these specific stages, unless they are stimulated by the hormone 1-methyladenine. In contrast, heterologous pairs develop up to female pronucleus formation in...