نتایج جستجو برای: associated neurodegeneration

تعداد نتایج: 1531207  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Ying Liu Mi-Jeong Yoo Alena Savonenko Wanda Stirling Donald L Price David R Borchelt Laura Mamounas W Ernest Lyons Mary E Blue Michael K Lee

beta-Amyloid (Abeta) pathology is an essential pathogenic component in Alzheimer's disease (AD). However, the significance of Abeta pathology, including Abeta deposits/oligomers and glial reactions, to neurodegeneration is unclear. In particular, despite the Abeta neurotoxicity indicated by in vitro studies, mouse models with significant Abeta deposition lack robust and progressive loss of fore...

2016
Mariko Saito Goutam Chakraborty Maria Hui Kurt Masiello Mitsuo Saito

Ethanol induces neurodegeneration in the developing brain, which may partially explain the long-lasting adverse effects of prenatal ethanol exposure in fetal alcohol spectrum disorders (FASD). While animal models of FASD show that ethanol-induced neurodegeneration is associated with glial activation, the relationship between glial activation and neurodegeneration has not been clarified. This re...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Yang Cao Stanislava Chtarbanova Andrew J Petersen Barry Ganetzky

A growing body of evidence in humans implicates chronic activation of the innate immune response in the brain as a major cause of neuropathology in various neurodegenerative conditions, although the mechanisms remain unclear. In an unbiased genetic screen for mutants exhibiting neurodegeneration in Drosophila, we have recovered a mutation of dnr1 (defense repressor 1), a negative regulator of t...

2014
Nuzhath Tajuddin Kwan-Hoon Moon S. Alex Marshall Kimberly Nixon Edward J. Neafsey Hee-Yong Kim Michael A. Collins

Evidence that brain edema and aquaporin-4 (AQP4) water channels have roles in experimental binge ethanol-induced neurodegeneration has stimulated interest in swelling/edema-linked neuroinflammatory pathways leading to oxidative stress. We report here that neurotoxic binge ethanol exposure produces comparable significant effects in vivo and in vitro on adult rat brain levels of AQP4 as well as n...

2013
David W Hampton Andrea Serio Gareth Pryce Sarah Al-Izki Robin JM Franklin Gavin Giovannoni David Baker Siddharthan Chandran

BACKGROUND [corrected] Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal substrate of secondary progression. In contrast to the increasing number of effective anti-inflammatory disease modifying treatments for relapse-remitting disease, the ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Ning Cheng Huaibin Cai Leonardo Belluscio

Amyloid precursor protein (APP) has long been linked to the neurodegeneration of Alzheimer's disease (AD), but the associated cell death has been difficult to capture in vivo, and the role of APP in effecting neuron loss is still unclear. Olfactory dysfunction is an early symptom of AD with amyloid pathology in the olfactory epithelium correlating well to the brain pathology of AD patients. As ...

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