We examined demographic, microbiologic, and clinical data from patients presenting during 1988, 1998, and 2004 flood-associated diarrheal epidemics at a diarrhea treatment hospital in Dhaka, Bangladesh. Compared with non-flood periods, individuals presenting during flood-associated epidemics were older, more severely dehydrated, and of lower socioeconomic status. During flood-associated epidemi...

abstract background and objectives: diarrhea is one of the main cases of morbidity and mortality among children in developing countries. enteroaggregative escherichia coli (eaggec) is an emerging diarrheal pathogen that has been associated characteristically with persistent diarrhea among infants, particularly in the developing counties. therefore, we decided to study the prevalence of enteroag...

OBJECTIVES Diarrhea is a frequent complication associated to enteral tube feeding (ETF) and it is a frequent cause of reduction or suspension of this type of nutritional support. Our objective was to evaluate the factors associated with nosocomial diarrhea in patients receiving ETF. RESULTS The only significant factor associated with the appearance of diarrhea was antibiotic consumption, spec...

Recent evidence has suggested the potential therapeutic role for probiotics in the prevention or treatment of gastrointestinal diseases. Several studies have shown that probiotics are of benefit in gastrointestinal infections, including viral diarrhea, Clostridium difficile-associated diarrhea, traveler's diarrhea, and antibiotic-associated diarrhea. Recent data support the potential beneficial...

BACKGROUND An estimated 1 million children die each year before their fifth birthday from diarrhea. Previous population-based surveys of pediatric diarrheal diseases have identified the protozoan parasite Entamoeba histolytica, the etiological agent of amebiasis, as one of the causes of moderate-to-severe diarrhea in sub-Saharan Africa and South Asia. METHODS We prospectively studied the natu...

Dhingra U, Kisenge R, Sudfeld CR, P, Somji S, Dutta A, et al. Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. N Engl J Med 2020;383:1231-41. Among children with diarrhea, what is the clinical efficacy of lower-dose zinc, compared to standard-dose in decreasing diarrhea and emesis – latter associated zinc? Non-inferior, randomized, controlled, double-blind study. India ...

BACKGROUND Klebsiella oxytoca was recently shown to be the causative agent of antibiotic-associated hemorrhagic colitis. Because it is unclear whether K. oxytoca also causes nonhemorrhagic antibiotic-associated diarrhea, our study investigated a possible association between K. oxytoca and that disorder. METHODS A total of 371 consecutive patients were recruited into 4 study groups: (1) group ...

A prospective, case-control study was performed in which enteric protein loss and nutritional status were measured in patients with symptomatic and asymptomatic infections due to Clostridium difficile. Enteric protein loss, measured by elevated levels of fecal alpha1-antitrypsin, was detected in 14 of 20 cases and controls with diarrhea (9 of 10 cases with C. difficile-associated diarrhea and 5...

Acute diarrhea associated with international travel is commonly caused by enterotoxigenic Escherichia coli, enteroaggregative E. coli, or noroviruses. Early studies to define these enteropathogens took place at the University of Maryland during the Theodore E. Woodward years. Although a reduction in the rate of diarrhea may be possible through avoidance of foods and beverages likely to be conta...

We investigated the epidemiological and clinical features of cryptosporidiosis, the molecular characteristics of infecting species and serum antibody responses to three Cryptosporidium-specific antigens in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients in Kenya. Cryptosporidium was the most prevalent enteric pathogen and was identified in 56 of 164 (34%) o...