A 23-year-old man who had previously undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia was diagnosed with invasive laryngeal-tracheobronchial-pulmonary aspergillosis after presenting with a persistent dry cough at six months post-transplantation based on the findings of laryngoscopy and fiberoptic bronchoscopy. A fiberoptic bronchoscope was used...

Pier Antonio Mitcheli, an Italian priest and biologist, discovered Aspergillus in 17291. The first description of aspergillosis in man was reported by Bennet in 18422. Since then different spectrums of the disease is known in man including invasive aspergillosis, aspergilloma and allergic bronchopulmonary aspergillosis. Sluyter was first to report pulmonary Aspergillosis in 18473 and Gerstyl re...

RATIONALE Primary cutaneous aspergillosis in immunocompromised patients has been well described in extensive investigations. However, in immunocompetent hosts, primary cutaneous infection of aspergillus occurs rarely, and remains poorly characterized. PATIENT CONCERNS We present a case of primary cutaneous aspergillosis manifested by erythematous plague covered with flava eschar. DIAGNOSES ...

This paper opens with a discussion on the significance of invasive fungal infections in advanced contemporary medicine, with an emphasis on the intractability of disease management and the difficulties of diagnosis. This is followed by a discussion concerning classification, histopathological features, and pathophysiology. While it has been largely accepted that Aspergillus species is recognize...

Outcomes of invasive aspergillosis are substantially improved with early initiation of therapy. Unfortunately, the diagnosis remains difficult to establish so that early suspicion of infection is imperative. Identification of high risk patients and use of non-culture-based diagnostics and radiographic studies can facilitate earlier recognition of infection. It is important to realize that the t...

Aspergillosis is recognized as an opportunistic infection in human and animals often occuring in association with other chronic diseases (immunodeficiency, diabetes mellitus, long-term antibiotherapy, chemotherapy, surgery, etc.). Over 95% of human aspergillosis are produced by A.fumigatus, A.flavus and A.niger commonly found in the environment. Primary cutaneous aspergillosis with A.flavus has...

The serological response to Aspergillus fumigatus was investigated in patients with pulmonary aspergillosis using the immunoblot technique. Antibody was detected against nine components of the fungus, ranging in molecular weight from 88 000 to 33 000 daltons. Antibody to a 40 000 dalton component was present in most patients (13 of 16). In surviving patients it was high (two with aspergilloma) ...

Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.