نتایج جستجو برای: as2o3

تعداد نتایج: 328  

Journal: :Molecular cancer therapeutics 2015
Elspeth M Beauchamp Ewa M Kosciuczuk Ruth Serrano Dhaval Nanavati Elden P Swindell Benoit Viollet Thomas V O'Halloran Jessica K Altman Leonidas C Platanias

Arsenic trioxide (As2O3) exhibits potent antineoplastic effects and is used extensively in clinical oncology for the treatment of a subset of patients with acute myeloid leukemia (AML). Although As2O3 is known to regulate activation of several signaling cascades, the key events, accounting for its antileukemic properties, remain to be defined. We provide evidence that arsenic can directly bind ...

2016
Fei-Fei Wang Ming-Zhu Liu Yi Sui Qing Cao Bo Yan Mei-Ling Jin Xi Mo

Small ubiquitin-like modifier (SUMO)/sentrin-specific protease 1 (SENP1), a member of the SENP family, is highly expressed in several neoplastic tissues. However, the effect of SENP1 in acute promyelocytic leukemia (APL) has not been elucidated. In the present study, it was observed that SENP1 deficiency had no effect on the spontaneous apoptosis or differentiation of NB4 cells. Arsenic trioxid...

Journal: :The Journal of biological chemistry 2003
Hélène Pelicano Li Feng Yan Zhou Jennifer S Carew Elizabeth O Hileman William Plunkett Michael J Keating Peng Huang

Cancer cells are under intrinsic increased oxidative stress and vulnerable to free radical-induced apoptosis. Here, we report a strategy to hinder mitochondrial electron transport and increase superoxide O2. radical generation in human leukemia cells as a novel mechanism to enhance apoptosis induced by anticancer agents. This strategy was first tested in a proof-of-principle study using rotenon...

Journal: :International Journal of Cancer and Biomedical Research (Print) 2021

Thesis Abstract Hexokinase 2 enzyme catalyzes the rate-limiting step in glycolysis. It is overexpressed several carcinomas including breast cancer to sustain energy for rapidly dividing cells and associates with chemoresistance. However, impact of chemo drugs alone or combination on hexokinase activity autophagic cell death unclear. Arsenic trioxide (As2O3) (ATO) a metalloid potent antineoplast...

2015
Jinshen Wang Lixia Wei Yueqin Han Daogang Qin Qiaozhi Yang Xiuli Ju

Haishengsu (Hss) is a purified protein from Tegillarca granosa that has been used as a traditional Chinese medicine to treat cancer for more than a century. In this study, we observed the impact of Haishengsu (Hss) on the proliferation and differentiation of HL-60 cells in the leukemic cell line by taking tretinoin and AS2O3 as a positive control and making a comparative analysis between the ef...

Journal: :Oncology reports 2008
Young-Hee Kang Su-Jae Lee

Enhancement of radiation response is possible to be achieved by combination treatment with therapeutic drugs. Previously we have shown that As2O3 in combination with ionizing radiation enhanced radiation response in cervical cancer cells. In this study, we further investigated molecular mechanism of synergistic enhancement of radiation response in combination with As2O3. The combination treatme...

2014
Elspeth M. Beauchamp Ewa M. Kosciuczuk Ruth Serrano Dhaval Nanavati Elden P. Swindell Benoit Viollet Thomas V. O'Halloran Jessica K. Altman Leonidas C. Platanias

Arsenic trioxide (As2O3) exhibits potent antineoplastic effects and is used extensively in clinical oncology for the treatment of a subset of patients with acute myeloid leukemia (AML). Although As2O3 is known to regulate activation of several signaling cascades, the key events, accounting for its antileukemic properties, remain to be defined. We provide evidence that arsenic can directly bind ...

Journal: :Blood 1997
A König L Wrazel R P Warrell R Rivi P P Pandolfi A Jakubowski J L Gabrilove

Inorganic arsenic trioxide (As2O3) was recently shown to induce apoptosis in NB4 promyelocytic leukemic cells. We have investigated the effects of the organic arsenical, melarsoprol (a drug used for treatment of trypanosomiasis), upon induction of apoptosis in cell lines representative of chronic B-cell lymphoproliferative disorders. An Epstein-Barr virus (EBV)-transformed B-prolymphocytic cell...

Journal: :Environmental Health Perspectives 1977
N Ishinishi Y Kodama K Nobutomo A Hisanaga

To investigate carcinogenic or cocarcinogenic properties, copper ore (Kinkaseki) and flue dust collected from a metal refinery and arsenic trioxide (As2O3) were administered into the lung of male Wistar-King rats by an intratracheal instillation method. No squamous cell carcinoma of the lung was found among the rats given three arsenical substances, while adenoma or adenocarcinoma was observed....

2003
Johanna M. Smeller Stefan D. Leigh

Bromate, a disinfectant, is one of the analytes of interest in wastewater analysis. Environmental laboratories have a regulatory need for their measurements to be traceable to NIST standards. Bromate is not currently certified as a NIST Standard Reference Material (SRM). Therefore, a traceable assay of potassium bromate (KBrO3) is needed. KBrO3 was dissolved in water and assayed by redox titrim...

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