FV100 is a promising new agent with extreme potency and specificity for varicella-zoster virus (VZV). It is the valyl ester pro-drug of Cf1743, the lead clinical candidate among the highly lipophilic bicyclic nucleoside analogue (BCNA) family discovered in Cardiff/Leuven. Cf1743 is unique amongst antivirals in terms of its structure and lipophilicity. It is exquisitely potent and selective for ...

Perlmutter (1970) argued that the indefinite article is categorically different from the definite article and proposed that it is a clitic version of the numeral "one". But there are, as Perlmutter himself pointed out, instances of "a" as well as of "one" that don't seem to have the semantics of the numeral. Hence a divorce of "a" (and of "one") from "numeral"-hood is called for. Furthermore, t...

The concepts of approximations in granular computing (GrC) vs. rough set theory (RS) are examined. Examples are constructed to contrast their differences in the Global GrC Model (2nd GrC Model), which, in pre-GrC term, is called partial coverings. Mathematically speaking, RS-approximations are “sub-base” based, while GrC-approximations are “base” based, where “sub-base” and “base” are two conce...

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