The present investigation was undertaken with an attempt to generate information pertaining to the assessment of arsenic residues in the vital organs like liver, lungs kidneys along with blood and hair as biomarker of chronic arsenic exposure using guinea pigs as experimental animal. For this purpose the guinea pigs were divided into two groups having 5 animals in each group. Group I animals we...

The present study was designed to investigate the in vivo effects of oral administration of arsenic trioxide (As2O3; 0.5 and 1 mg/kg body weight/day for 45 days) on cerebral hemispheres and cerebellum in male mice, Mus musculus. Arsenic reduced the concentration of glutathione (GSH) in cerebral hemisphere and cerebellum at both the dose levels; while increased lipid peroxidation (LPO) in cerebr...

poisons is arsenic, though the arsenic in question was generally not the pure chemical element itself but rather its oxide, As2O3 or diarsenic trioxide, otherwise known with equal inaccuracy as white arsenic. Indeed, since the most common form of this compound is actually composed of discrete As4O6 molecules, it should more properly be called tetraarsenic hexaoxide. For centuries proof of arsen...

The serious arsenic contamination of groundwater in Bangladesh has come out recently as the biggest natural calamity in the world. The people in 59 out of 64 districts comprising 126,134 km of Bangladesh are suffering due to the arsenic contamination in drinking water. Seventy five million people are at risk and 24 million are potentially exposed to arsenic contamination. Most of the recognized...

The objective of this study was to design and evaluate a household-level arsenic education and well water arsenic testing intervention to increase arsenic awareness in Bangladesh. The authors randomly selected 1,000 study respondents located in 20 villages in Singair, Bangladesh. The main outcome was the change in knowledge of arsenic from baseline to follow-up 4 to 6 months after the household...

The aim of the present study was to evaluate Vitamin C (VC) as a potent natural antioxidant to mitigate the genotoxic effects of Arsenic trioxide and sodium fluoride in Swiss albino mice in vivo. The study was divided into eight groups consisting of control treated with normal saline (Group I), Group II, III, IV, V, VI, VII and the VC group with only Vitamin C (500 mg/kgbw). Arsenic trioxide (4...

The present study was undertaken to examine if microdoses of ultra-high diluted arsenic trioxide (a potentized homeopathic remedy, Arsenicum Album 200C, diluted 10(-400) times) have hepatoprotective potentials in mice subjected to repeated injections of arsenic trioxide. Arsenic intoxicated mice were divided into: (i) those receiving Arsenicum Album-200C daily, (ii) those receiving the same dos...

INTRODUCTION Homeopathy uses information gathered from healthy volunteers taking homeopathic substances (pathogenetic trials) for clinical treatment. It is controversial whether such studies produce symptoms different from those produced by placebo. OBJECTIVE To test whether homeopathic preparations produce different symptoms than placebo in healthy volunteers. METHODS Three armed, double-b...