the purpose of the present study was to investigate the effect of polyethylene glycol (peg) molecular weights (6000, 12000 and 20000) as solid dispersion (sd) carriers on the dissolution behavior of simvastatin. sds with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. differential scanning calorimetry (dsc), x-ray diffraction (xrd), infrared spe...

BACKGROUND Since 2005, the antiepileptic drug lamotrigine has been present in the market in various generic products, in addition to the original brand of Lamictal®. The linear pharmacokinetics and wide therapeutic window of lamotrigine enable seizure-free patients to easily switch from brand to generic antiepileptic drugs. OBJECTIVE The aim of this study was to investigate the extent of vari...

The main purpose of the present investigation is to enhance the solubility and bioavailability of poorly watersoluble atorvastatin calcium (ATR) through the self nanoemulsifying drug delivery system (SNEDDS).The components for self-nanoemulsion were identified by solubility studies and tendency for self-emulsification in various excipients. Sefsol 218, Cremophor RH 40 and Propylene glycol were ...

Dissolution of nonaqueous-phase liquids (NAPLs) from variable-aperture fractures couples fluid flow, transport of the dissolved NAPL, interphase mass transfer, and the corresponding NAPL-water-interface movement. Each of these fundamental processes is controlled by fracture-aperture variability and entrapped-NAPL geometry. We develop a depth-averaged computational model of dissolution that inco...

The aim of this investigation was to improve the dissolution properties of the water-insoluble drug ezetimibe (EZE) and potentially improve bioavailability. A combination of melt and adsorption techniques was employed for the preparation of solid dispersions. PEG 4000, PEG 6000, and Gelucire 44/14 were used as hydrophilic carriers, and lactose monohydrate was used as an adsorbent. Phase solubil...

The study was aimed to investigate the effect of dissolution enhancement on hypolipidemic and hepatotoxicity drug in hyperlipidemic rats. Atorvastatin ascorbic acid cocrystals were prepared by phase solution methods characterized Fourier transformation infrared spectroscopy, differential scanning calorimetry, electron microscopy, X-Ray powder diffraction. Results characterization confirmed that...

Methods for rapid and cost-effective assessment of the biotransformation potential of very hydrophobic and potentially bioaccumulative chemicals in mammals are urgently needed for the ongoing global evaluation of the environmental behavior of commercial chemicals. We developed and tested a novel solvent-free, thin-film sorbent-phase in vitro dosing system to measure the in vitro biotransformati...

In vitro dissolution tests for solid oral dosage forms are extremely important to ensure the quality of these products. However, no dissolution test has been reported for finasteride (FNS) in immediate-release capsules. The aims of this work were to optimize a dissolution method for FNS capsules, validate the analytical method, and evaluate three different commercial products. The best in vitro...

The aim of this study was to develop and validate a dissolution test for the quality control of deflazacort (DEF) tablets, a drug mainly used for the prevention of organ transplantation rejection, labeled as containing 6 mg of active pharmaceutical ingredient (API), using an RP-HPLC method. After testing sink conditions and stability at 37°C, DEF was found to be unstable, and decomposed as a fu...