Purpose. Mild cognitive impairment (MCI) is considered an "at risk" state for dementia and efforts are needed to target modifiable risk factors, of which Obstructive sleep apnoea (OSA) is one. This study aims to evaluate the predictive utility of the multivariate apnoea prediction index (MAPI), a patient self-report survey, to assess OSA in MCI. Methods. Thirty-seven participants with MCI and 3...

The t-test is as defined in the previous lecture. It has slope 1/σ. The Mann-Whitney test rejects if 1 nm ∑ i,j I(Xi ≤ Yj) is large. Note. The Mann-Whitney statistic has a relationship with the area under the ROC curve (AUC) for classification algorithms with a tunable parameter. The ROC plot has one axis for proportion of false positives and one axis for proportion of true positives; as we mov...

Hemophagocytosis, a phenomenon of which activated macrophages phagocytosed hematopoietic elements was reportedly observed in severe dengue patients. In the present study, we investigated whether markers of macrophage activation syndrome (MAS) can be used as differential diagnostic markers of severe dengue. Two hundred and eight confirmed dengue patients were recruited for the study. Sandwich EL...

This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard. Derived indexes of accuracy, in particular area under the curve (AUC) has a meaningful interpretation for disease classification from healthy subjects. The methods of estimate of AUC and its testing in single diagnostic test and also comparative studies...

Receiver operating characteristic (ROC) curves and in particular the area under the curve (AUC), are widely used to examine the effectiveness of diagnostic markers. Diagnostic markers and their corresponding ROC curves can be strongly influenced by covariate variables. When several diagnostic markers are available, they can be combined by a best linear combination such that the area under the R...

We investigated and evaluated the detection of simulated lesions in various interstitial lung diseases using the dual-energy subtraction radiography method and flat-panel detector (FPD) images. We obtained a FPD system (GE Revolution XR/d), and employed dual-energy 60 kV and 130 kV exposure techniques. Three types of lung lesions, namely, micro-nodule, ground-glass, and honeycomb patterns were ...

BACKGROUND The correct identification of patients with Parkinson disease (PD) at risk for falling is important to initiate appropriate treatment early. OBJECTIVE This study compared the Fullerton Advanced Balance (FAB) scale with the Mini-Balance Evaluation Systems Test (Mini-BESTest) and Berg Balance Scale (BBS) to identify individuals with PD at risk for falls and to analyze which of the it...

Sensitivity and specificity are two components that measure the inherent validity of a diagnostic test for dichotomous outcomes against a gold standard. Receiver operating characteristic (ROC) curve is the plot that depicts the trade-off between the sensitivity and (1-specificity) across a series of cut-off points when the diagnostic test is continuous or on ordinal scale (minimum 5 categories)...

The Receiver Operating Characteristic (ROC) curve is a two dimensional measure of classification performance. The area under the ROC curve (AUC) is a scalar measure gauging one facet of performance. In this note, five idealized models are utilized to relate the shape of the ROC curve, and the area under it, to features of the underlying distribution of forecasts. This allows for an interpretati...