8,9-Dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6] naphthyridin-6-one (ARC-111, topovale) is a new synthetic antitumor agent. In the current study, we show that ARC-111 is highly potent in scid mice carrying human tumor xenografts. ARC-111 was shown to be as active as camptothecin (CPT)-11 in the HCT-8 colon tumor model, and compared favorably with CPT-11 and top...

Arctigenin (ARC) has been shown to have an anti-cancer effect in various cell types and tissues. However, there have been no studies concerning metastatic colorectal cancer (CRC). In this study, we investigated the anti-metastatic properties of ARC on colorectal metastasis and present a potential candidate drug. ARC induced cell cycle arrest and apoptosis in CT26 cells through the intrinsic apo...

Constraint satisfaction problems (CSP's) naturally occur in a number of important industrial applications, such as planning, scheduling and resource allocation. GENET is a neural network simulator to solve binary constraint satisfaction problems. GENET uses a convergence procedure based on a relaxed form of local consistency to nd assignments which are locally minimal in terms of constraint vio...

We consider visibility graphs involving bars and arcs in which lines of sight can pass through at most k objects. We prove a new edge bound for arc k-visibility graphs, provide maximal constructions for arc visibility graphs and semi-arc k-visibility graphs, and give a complete characterization of semi-arc visibility graphs. We further show that the family of arc i-visibility graphs is never co...

Human genetic studies have recently suggested that the postsynaptic activity-regulated cytoskeleton-associated protein (Arc) complex is a convergence signal for several genes implicated in schizophrenia. However, the functional significance of Arc in schizophrenia-related neurobehavioral phenotypes and brain circuits is unclear. Here, we find that, consistent with schizophrenia-related phenotyp...

Synaptic efficacy following long-term potentiation (LTP) and memory consolidation is associated with changes in the expression of immediate early genes (IEGs). These changes are often accompanied by increased expression of glial fibrillary acidic protein (GFAP). While the protein products of the majority of IEGs are mainly restricted to the cell body, Arg3.1/Arc product is rapidly delivered to ...

Hypophysiotropic somatostatin (SRIF) and growth hormone-releasing hormone (GHRH) neurons are primarily involved in the neurohormonal control of growth hormone (GH) secretion. They are located in periventricular (PEV) and arcuate (ARC) hypothalamic nuclei, respectively, but their connectivity is not well defined. To better understand the neuronal network involved in the control of GH secretion, ...

Sensing plays a key role in automating and controlling welding processes. Although arc light sensing has advantages over through-the-arc sensing for arc length control and seam tracking, the current technology relies on experimental data and lacks theoretical foundation. To improve measurement accuracy, this work addresses the theoretical foundation for arc light sensing. A theoretical model ha...

Although exogenous administration of beta-endorphin to the arcuate nucleus of hypothalamus (ARC) had been shown to produce antinociception, the role of endogenous beta-endorphin of the ARC in nociceptive processing has not been studied directly. The aim of the present study was to investigate the effect of endogenous beta-endorphin in the ARC on nociception in rats with carrageenan-induced infl...

The Izu-Bonin arc (IBA) has been colliding with the Honshu arc since the middle Miocene, which together form the active Izu arc-arc collision zone (ICZ) in central Japan. To understand the entire collisional system, we have used refraction/wide-angle reflection data to model velocity structures of the Honshu arc, northwest of the ICZ. The seismic data indicate that the upper 4-km crust of the H...