نتایج جستجو برای: ar

تعداد نتایج: 61795  

2014
Cheng-Lung Hsu Jai-Shin Liu An-Chi Lin Chih-Hsun Yang Wen-Hung Chung Wen-Guey Wu

Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence the AR or its downstream signaling. These tests revealed that minoxidil suppressed AR-related functions, decreasing AR transcriptional activity i...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Xiangcang Ye Sang Jun Han Sophia Y Tsai Francesco J DeMayo Jianming Xu Ming-Jer Tsai Bert W O'Malley

Genetic disruption of the steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF)2/SRC-2 in mouse resulted in distinctive mutant phenotypes. To quantify their roles in the function of androgen receptor (AR) transcriptional activity in vivo, we generated a unique transgenic AR-reporter mouse and analyzed the cell-specific contributions of SRC-1 and TIF2 to the activity...

Journal: :Revista del Instituto de investigación de la Facultad de geología, minas, metalurgia y ciencias geográficas de la Universidad nacional mayor de San Marcos 2022

El presente estudio de investigación demuestra que es viable la recuperación oro y zinc en minerales marmatitico con contenido oro. Se analizó mediante diseños experimentales factoriales, utilizando los reactivos: CuSO4, AR-3418 AR-1242 como variables independientes; el resto las se mantuvieron constantes.
 Como resultado obtuvo un modelo para zinc, realizando análisis del diseño factorial...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شیراز - دانشکده علوم 1369

وقتی دو گاز مختلف که از لحاظ شیمیائی خنثی میباشند را در یک سیستمی تحت د حرارت و فشار ثابت قرار دهیم طوری که این دو گاز این امکان برایشان بوجود آی که در هم منتشر شوند، در اثر این انتشار تغییر درجه حرارت گذرائی ایجاد میگردد، این پدیده را اثر گرمائی انتشار مینامند. این اثر اولین بار در سال 1872 توسط دوفر مشاهده گشت ، ولی تا سال 1942 که دوباره توسط کلاوسیون و والدمن مورد بررسی واقع گردید به فراموشی...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تبریز - دانشکده ریاضی 1393

در این پایان نامه یک روش تکراری برای پیدا کردن جواب های دومتقارن معادله ی ماتریسی ‎‎ ‎$ a_1x_1b_1+a_2x_2b_2+dots+a_lx_lb_l=c $‎ که ‎$ [x_1,x_2,dots,x_l] $‎ دسته ماتریس های حقیقی می باشد، ساخته شده است. به وسیله ی این روش تکراری، حل پذیری معادلات ماتریسی تشخیص داده می شود. زمانی که معادله ی ماتریسی سازگار است، برای هر دسته ماتریس دومتقارن اولیه ی ‎$ [x_1^{(0)},x_2^{(0)},dots,x_l^{(0)}] $‎، یک...

Journal: :American journal of clinical and experimental urology 2017
Fengtian Wang Hari K Koul

Despite the progress in development of better AR-targeted therapies for prostate cancer (PCa), there is no curative therapy for castration-resistant prostate cancer (CRPC). Therapeutic resistance in PCa can be characterized in two broad categories of AR therapy resistance: the first and most prevalent one involves restoration of AR activity despite AR targeted therapy, and the second one involv...

Journal: :Asian journal of andrology 2009
Hai-Lei Mao Zhi-Qi Zhu Charlie Degui Chen

Advanced prostate cancer is responsive to hormone therapy that interferes with androgen receptor (AR) signalling. However, the effect is short-lived, as nearly all tumours progress to a hormone-refractory (HR) state, a lethal stage of the disease. Intuitively, the AR should not be involved because hormone therapy that blocks or reduces AR activity is not effective in treating HR tumours. Howeve...

2015
Jianquan Guo Xuemei Huang Hui Wang Huanjie Yang Zoran Culig

Autophagy is an evolutionarily conserved process responsible for the degradation and recycling of cytoplasmic components through autolysosomes. Targeting AR axis is a standard strategy for prostate cancer treatment; however, the role of AR in autophagic processes is still not fully understood. In the present study, we found that AR played a negative role in AR degrader celastrol-induced autopha...

2003
E. T. Dixon D. D. Bogard A. E. Rubin

Introduction: Miller Range 99301 is a type 6, unbrecciated LL chondrite [1]. MIL 99301 is of interest because some compositional and petrographic features suggest it experienced rather high shock grades, whereas other features suggest it is relatively unshocked. Inconsistent shock indicators could be explained if MIL 99301 was shocked but then partly annealed by heat produced by impacts on the ...

2003
M. Châtelet

A comparison of the adsorption efficiencies for Ar atoms on large (N2)m (m = 1320−10600) clusters and N2 molecules on large (Ar)n (n = 7900−17000) clusters has been investigated by the pick-up technique. Using mass spectroscopy, it has been shown that mixed (Ar)n(N2)m clusters can be created either by depositing Ar atoms from buffer gas on the surface of (N2)m clusters or by depositing N2 molec...

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