BACKGROUND Crocus sativus, known as saffron crocus, is best known for the spice saffron. Saffron use spans more than 3500 years, however, its toxicity on neonates during lactation has not yet evaluated. OBJECTIVES This study was aimed to examine the acute toxicity of saffron on adult mice and its nephrotoxicity and hepatotoxicity on neonates of lactating mothers that used saffron during lacta...

In this study, total crocin was extracted from saffron stigmas using crystallization method. Ethanol 80% was selected as the best extraction solvent. Crystallization process was carried out in one and two steps at different temperatures. Ethanol 80% was used as crystallization medium. Crocin crystals obtained from the first crystallization had low purity and thus were subjected to the second cr...

We recently identified saffron cod Eleginus gracilis as a dominant fish species in nearshore habitats (<5 m deep, <20 m offshore) of western Prince William Sound (PWS), Alaska, USA. Saffron cod have not been previously reported in PWS, and their capture suggests that fish community structure has changed in nearshore habitats. Nearly 16 000 saffron cod were captured in 49 of 95 beach seine hauls...

      Current therapies for breast cancer are often limited by short-term efficacy due to the emergence of drug resistance. There has been increased interest in the use of naturally occurring compounds with chemopreventive and chemotherapeutic effects in the treatment of cancers. Saffron, dry stigmas Crocus sativus L., used in Iran as a spice, is known for its anticancer properties. In...

the aim of this study was to assess the efficacy and tolerability of the aqueous extract of echium amoenum in combination with ssris in patients with general anxiety disorder (gad). the study was an 8-week double-blind randomized clinical trial. thirty-seven adult outpatients who met the dsm-iv-tr criteria for gad based on the structured clinical interview participated in the trial. in this stu...

preliminary studies revealed that urtica dioica has been known as a plant that decrease blood glucose. despite the importance of this plant in herbal medicine, relatively little research has been down on effects of this plant on islets yet. the objective of the current study was to evaluate the effect of dried urtica dioica leaf alcoholic and aqueous extracts on the number and the diameter of t...

background : the study was aimed to show the effect of molecular mechanism of aqueous garlic extract (age) on expression of ifnγ and inos genes in leishmania major . methods : leishmania major promastigotes (mrho/ir/75/er) were added to the in-vitro cultured j774 cell line, the cells were incubated for 72 hours. various concentrations of garlic extract (9.25, 18.5, 37, 74, 148 mg/ml) were added...

background: teucrium polium has been known as an important traditional medicinal plant and is used for different therapeutic purposes such as gastrointestinal disorders. therefore, the anti-spasmodic and antinociceptive activities of aqueous extract of teucrium polium w as examined. methods: anti-spasmodic effect of different concentrations (47-470 mg/l) of teucrium polium extract was assessed ...