Withania somnifera Dunal (WS), commonly known as Ashwagandha in India, belongs to the family Solanaceae. It is extensively used in most of the Indian herbal pharmaceuticals and nutraceuticals. In the current study, the in vitro cytotoxic activity of methanolic, ethanolic, and aqueous extracts of WS stems was evaluated using cytometry and the MTT assay against the MDA-MB-231 human breast cancer ...

Background: Drugs dedicated to alleviate neurodegenerative diseases like Parkinson’s and Alzheimer’s have always been associated with debilitating side effects. Medicinal mushrooms which harness neuropharmacological compounds may be a promising avenue for protection against such diseases. Panus giganteus (Berk.) Corner has been consumed by the indigenous people in Peninsular Malaysia for many y...

This investigation is designed to evaluate the potential hepato-protective effect of ethanolic and aqueous extracts of air-dried leaves of Purslane against paracetamol-induced hepato-toxicity, in an attempt to understand its mechanism of action, which may pave the way for possible therapeutic application. Paracetamol (1g/kg bw) administration to rats resulted in massive elevation in serum and h...

objective(s) in the present study, the effects of aqueous-ethanolic extract from rosa damascena on heart rate and contractility were examined. materials and methods isolated guinea-pig hearts were perfused through aorta in a langendorff mode. heart rate (hr) and contractility were determined in the presence of four concentrations of the extract (0.1, 0.2, 0.4 and 1.0 mg %) and isoprenaline (1, ...

Background and Purpose: Oral candidiasis is one of the most common fungal infections in humans. The treatment and prophylaxis of the patients suffering from this infection require the identification of new anti-Candida agents with no side effects or toxicity like medicinal plants. The present study was conducted to compare the antifungal activities of the aqueous, ethanolic, and methanolic extr...

Background and Aim: In recent years, due to the indiscriminate and irrational use of synthetic drugs, the resistance of pathogenic microorganisms has increased; therefore, new compounds are vitally needed. The purpose of this study was to investigate the effect of ethanolic and aqueous extracts of Berberis vulgaris on Escherichia coli, Klebsiella pneumoniae, Proteu...

Taguchi orthogonal array design is a statistical approach that helps to overcome limitations associated with time consuming full factorial experimental design. In this study, the Taguchi orthogonal array design was applied to establish the optimum conditions for bovine serum albumin (BSA) nanocarrier (ANC) preparation. Taguchi method with L9 type of robust orthogonal array design was adopted to...