As countries scale up adult voluntary medical male circumcision (VMMC) for HIV prevention, they are looking ahead to long term sustainable strategies, including introduction of early infant male circumcision (EIMC). To address the lack of evidence regarding introduction of EIMC services in sub-Saharan African settings, we conducted a simultaneous, prospective comparison of two models of EIMC se...

Over 400 million people living in the world's poorest developing nations are infected with hookworms, mostly of the genus Necator americanus. A bivalent human hookworm vaccine composed of the Necator americanus Glutathione S-Transferase-1 (Na-GST-1) and the Necator americanus Aspartic Protease-1 (Na-APR-1 (M74)) is currently under development by the Sabin Vaccine Institute Product Development P...

Pioneer Award (DP1OD003874). Java Code for the model is available from the authors upon request.. CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. doi: bioRxiv preprint first posted online Apr. 24, 2014;. CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is m...

Although chemotherapeutic drugs could theoretically target all metastatic sites, current treatments do not provide complementary therapeutics. Therefore, the development of an alternative approach replacing the traditional therapy is urgently needed. To assess the killing efficiency of the functionally identified apoptosis-related protein (APR)-1 in melanoma cells, we established a system for t...

Rusts, a fungal disease as old as its host plant wheat, has caused havoc for over 8000 years. As the rust pathogens can evolve into new virulent races which quickly defeat the resistance that primarily rely on race specificity, adult plant resistance (APR) has often been found to be race non-specific and hence is considered to be a more reliable and durable strategy to combat this malady. Over ...

five-year disease-specific survival for the entire cohort was 34%, with a median follow-up of 39 months for survivors. Thirty-four (74%) of 46 patients relapsed, with a median relapse-free survival of 10 months and an overall recurrence rate of 53% at 1 year. The majority of patients developed distant recurrences. No differences were seen in patterns of relapse between patients treated with an ...

The research presented in this paper is concerned with the development of an automatic phone recogniser (APR) that converts an acoustic speech signal into a phone string, that meets the criterion that the number of phones should be ‘correct’. Two methods are investigated, viz. the optimisation of the APR on the ‘number of phones’ criterion and the introduction of variants in the phonetic transc...

On the use of administrative databases to support planning activities: a comment Sir, The paper by Fantini et al. 1 rightly stresses the importance in health care planning of identifying centres that treat more severe (complex) cases. However, in their evaluation of the ability of two software packages, Medicare Diagnosis Related Groups (Medicare DRG) and All Patient Refined Diagnosis Related G...