Apoptosis is not only pivotal for development, but also for pathogen defence in multicellular organisms. Although numerous intracellular pathogens are known to interfere with the host's apoptotic machinery to overcome this defence, its importance for host-parasite coevolution has been neglected. We conducted three inoculation experiments to investigate in the apoptotic respond during infection ...

Examination of apoptotic cell surface molecules has so far failed to reveal cell type-specific membrane alterations that serve as a signal for phagocytosis. In the present study we have identified a novel murine monoclonal antibody, BOB93, which bound to the surface of apoptotic neutrophils but not to apoptotic lymphocytes. BOB93 binding to apoptotic neutrophils was dependent on the presence of...

In this study, the complete cDNA sequence (1552 bp) of cold-inducible RNA binding protein gene (cirbp gene) was successfully cloned from liver in Acanthopagrus schlegelii (initial weight: 15.0 ± 2.3 g). Results showed that Ascirbp A. schlegelii) has 24 phosphorylation sites, no signal peptide, and transmembrane helix structure. AsCIRBP, with a molecular weight 18.84 ku an isoelectric point 9.04...

Background: Adenosine plays the role of regulating cell differentiation, proliferation, and apoptosis in various kinds cells through B-cell lymphoma 2 (BCL2) pathway. Objectives: Since anti-apoptotic expression a controlling some lines, this study was designed to investigate whether adenosine analogue, NECA (non-selective receptors agonist), selective A2B receptor antagonist, PSB 603, A2A agoni...

TRAIL is a member of the TNF superfamily that induces tumor-selective cell death by engaging the pro-apoptotic death receptors DR4 and DR5. The antitumor potential of the TRAIL pathway has been targeted by several therapeutic approaches including recombinant TRAIL and TRAIL-receptor agonist antibodies among others. Interest in sensitizing tumor cells to TRAIL-mediated apoptosis has driven inves...

Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of water extract senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231).Methods: The MTT assay was to assess proliferation. expression apoptosis-related genes assessed by quantitative real-time PCR.Results: ASF treatme...