نتایج جستجو برای: apoptosis related genes

تعداد نتایج: 1644143  

Journal: :International journal of clinical and experimental medicine 2015
Lianshu Han Shengnan Wu Feng Han Xuefan Gu

Methylmalonic acidemia (MMA) is widely considered as an autosomal recessive metabolic disorder that results in accumulation of high levels of methylmalonic acid and eventually brain damage. This study aims to investigate the effects of methylmalonic acid on neurons and analyze various gene expression profiles in rat cortical neurons treated with methylmalonic acid in order to understand the eff...

2007
Dmitriy Ovcharenko Kevin Kelnar Charles Johnson Nan Leng David Brown

Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) binds to death receptors 4/5 and selectively induces caspase-dependent apoptosis. The RNA interference screening approach has led to the discovery and characterization of several TRAIL pathway components in human cells. Here, libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA) were used to probe the TRAIL pat...

2012
Tatjana Khromov Ralf Dressel Iliana Siamishi Jessica Nolte Lennart Opitz Wolfgang Engel D. V. Krishna Pantakani

Stem cells in the developing embryo proliferate and differentiate while maintaining genomic integrity, failure of which may lead to accumulation of mutations and subsequent damage to the embryo. Embryonic stem cells (ESCs), the in vitro counterpart of embryo stem cells are highly sensitive to genotoxic stress. Defective ESCs undergo either efficient DNA damage repair or apoptosis, thus maintain...

Journal: :Cancer research 2007
Dmitriy Ovcharenko Kevin Kelnar Charles Johnson Nan Leng David Brown

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to death receptors 4/5 and selectively induces caspase-dependent apoptosis. The RNA interference screening approach has led to the discovery and characterization of several TRAIL pathway components in human cells. Here, libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA) were used to probe the TRAIL pat...

بشاش, داود, صفراوغلی آذر, آوا, نعمتی منصور, فهیمه, پورباقری سیگارودی, عطیه,

Background and purpose: Telomerase activity has a major role in acute promyelocytic leukemia (APL). It also has a critical role in disease recurrence. This research aimed at studying the cytotoxic effects of telomerase inhibition using oligonucleotide-based molecule against human telomerase RNA template (hTERC antisense) and non-nucleoside small molecule targeting catalytic subunit (BIBR5132) o...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005
Teodora Nikolova Jaroslaw Czyz Alexandra Rolletschek Przemyslaw Blyszczuk Jörg Fuchs Gabriele Jovtchev Jürgen Schuderer Niels Kuster Anna M Wobus

Mouse embryonic stem (ES) cells were used as an experimental model to study the effects of electromagnetic fields (EMF). ES-derived nestin-positive neural progenitor cells were exposed to extremely low frequency EMF simulating power line magnetic fields at 50 Hz (ELF-EMF) and to radiofrequency EMF simulating the Global System for Mobile Communication (GSM) signals at 1.71 GHz (RF-EMF). Followin...

Journal: :Food Science and Technology 2023

Cell apoptosis induction and metastasis suppression in human breast cancer cell, MDA-MB-231, were studied to assess the potential of Cirsium setidens extract (CSE) on treatment. viability analysis using MDA-MB-231 confirmed CSE significantly inhibited growth proliferation cell without suppressing normal range 0.25 0.5 mg/mL CSE. To analyze anticancer effect CSE, expressions major genes related ...

Gholamhossin Hassanshahi MalekHosein Asadi Mohammad Reza Mirzaei, Seyed Javad Mowla, Zahra Ahmadi,

Objective(s): The OCT4B1, as one of OCT4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. The present study was designed to determine the effects of OCT4B1 silencing on expressional profile of HSP40 gene family expression in three different human tumor cell lines. Materials and Met...

Journal: :hepatitis monthly 0
shahryar khoshtinat nikkhoi department of medical biotechnology, faculty of medical sciences, tarbiat modares university, tehran, ir iran; baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran hedieh heydarzadeh department of microbiology, faculty of science, azad university of shahreh qods, tehran, ir iran saeed ranjbar department of medical biotechnology, faculty of medical sciences, tarbiat modares university, tehran, ir iran fatemeh salimi department of medical biotechnology, faculty of medical sciences, tarbiat modares university, tehran, ir iran masoud aghaeifard department of hematology, faculty of medical sciences, tarbiat modares university, tehran, ir iran seyed moayed alavian baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran; professor of gastroenterology and hepatology baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran. tel: +98-9121073195

methods the current study generated two recombinant lentiviruses, plex-gcn and plex-gcp, bearing noxa and puma, respectively. transduction of both genes to hepatocarcinoma (hepg2) was verified using fluorescent microscopic analysis, western blotting, and quantitative real-time polymerase chain reaction (pcr). to evaluate the potential of noxa and puma to initiate apoptosis, a caspase-9 real-tim...

2015
Bin Yu Bin Zhang Wen-bo Zhou Qiu-wei Wang Pei Yuan Yu-qi Yang Jing Kong

It is well known that Down syndrome (DS) is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. Intellectual disability is the foremost and most debilitating trait, which caused loss of cognitive abilities and the development of early onset Alzheimer's disease (AD). Ts65Dn mice were used in this study. We isolated the hippocampus....

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