background: complete and fast diagnosis, registry and treatment programs are the main effective strategies for controlling infectious diseases. in addition, an organized and extended infectious disease surveillance system is crucial in designing and monitoring communicable diseases control programs. the quality of the surveillance system can be evaluated by several indices such as timeliness, c...

background: cytomegalovirus (cmv) disease is an important cause of death and possibly transplant rejection in kidney transplant (kt) patients. this study was conducted to investigate the incidence and risk factors of cmv disease in kidney transplant patients. methods: all end-stage renal disease (esrd) patients who underwent kidney transplantation during 1998-2014 and their donors were assessed...

background : cancer incidence rate is increasing in the world particularly in developing countries. the awareness regarding cancer incidence and distribution helps policy makers and researchers to design comprehensive plan for controlling cancer. the aim of this study was to determine the incidence rate and trend of cancer in yazd province, centeral iran. methods : data from yazd cancer registr...

background : hamadan is a province with high incidence rate of suicide. the present study was conducted to assess suicide and its associated risk factors in this province. methods : in this cross-sectional study, all cases of suicide occurred in the province, were investigated from april 2008 to march 2010. the data were collected from provincial health center and forensic medicine's databases ...

Chronic exposure to peroxisome proliferators (PPs) leads to increased incidence of liver tumors in rodents. Liver tumor induction is thought to require increased hepatocyte proliferation and suppression of apoptosis. Transcript profiling showed increased expression of proapoptotic genes and decreased expression of antiapoptotic genes in the livers of mice exposed to the PP WY-14,643 (WY). We te...

background: silymarin is a flavonolignan that has been the subject of research to evaluate the beneficial properties for decades. silymarin has been known for its potent cytoprotective, hepatoprotective and antioxidant activities. the goal of the present study was to gain a deeper understanding of possible molecular mechanisms of apoptosis of the injuries induced by silymarin on balb/c mice fet...

objective(s): the role of aluminum (al) in the pathogenesis of neurodegenerative diseases has been implicated in several studies. however, the exact mechanisms of cytotoxic effects of al have not been elucidated yet. the aim of this study was to investigate the effect of l-type calcium channel antagonist, nimodipine (nm), and lithium chloride (licl) on al-induced toxicity in pc12 cells. materia...

background: there is accumulating evidence that a polyphenol present in olive oil, oleuropein, has antioxidant, anti-inflammatory and anti-apoptotic effects. this study aimed at determining the anti-apoptotic effect of oleuropein (ole) on dexamethasone-induced apoptosis of mouse thymocytes. method: mice were randomly divided to four groups as follow: dexamethasone (dex)-treated group (20 mg/kg;...

background physical activity and alteration of temperature as a source of stress may have adverse effects on male reproduction. objectives the aim of this study was to investigate the effect of chronic swimming and standing in cold, warm and lukewarm water on mouse spermatogenesis. materials and methods forty-nine male mice (n = 49) were randomly divided into seven groups: c, control; swc, swim...

Abstract Study question Are there cell lineage-related differences in the apoptotic rates of human blastocysts classified as euploid, mosaic and aneuploid after preimplantation genetic testing for aneuploidy (PGT-A)? Summary answer In blastocysts, apoptosis is more frequent trophectoderm (TE) cells associated with presence uniform chromosomal alterations. What known already Embryos diagnosed PG...