Purpose PFAPA is an autoinflammatory syndrome of childhood characterized by recurrent attacks of fever, aphthous stomatitis, pharyngitis and adenitis. The underlying immune disorder is poorly understood, albeit activation of Th1 related cytokines has been observed. We aimed to compare concentration of proinflammatory cytokines and selected chemokines in PB during and between febrile episodes in...

Introduction Periodic Fever, Aphthous stomatitis, Pharyngitis and Adenitis (PFAPA) syndrome is an autoinflammatory disorder of childhood and little is known about the underlying etiology. While mutations involving the IL-1 pathway have been identified in other recurrent fever disorders, including TNF-receptor associated periodic syndrome (TRAPS) and cryopyrin-associated periodic syndrome (CAPS)...

recurrent aphthous stomatitis (ras) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. ras appears to be associated with some human leukocyte antigen (hla) class ii alleles and haplotypes. this study attempts to survey the distribution of hla-drb and -dqb alleles among iranian ras patients and healthy controls. in order to evaluate ...

conclusions the plants listed can be used as a prediction of rau management. of course, there are is no evidence for curing rau by some of these plants in allopathic medicine, and the further investigations in this area could lead to the discovery of a new drug evidence acquisition iranian medical sources were reviewed and effective plants used in the traditional treatment of rau were found and...

GOALS AND BACKGROUND European studies have demonstrated that dental enamel defects and oral aphthae are observed in celiac disease (CD). We investigated this association in a US population. STUDY Biopsy proven CD patients and controls were recruited from a private dental practice and from CD support meetings. History of aphthae was taken and dental examination was performed by a single dentis...

Behqet's disease (BD) is best considered as a systemic vasculitis in which recurrent orogenital ulceration is a prominent feature. In 1937 Hulusi Behqet described the syndrome that bears his name' but the term 'BehNet's disease' is now used in preference to 'Behqet's syndrome'. Behqet, himself, recognized the problems related to its diagnosis for which there remains no diagnostic test. BD is ra...

OBJECTIVE To make Pediatricians aware of the fact that they must investigate Behçet's disease while performing differential diagnosis of recurrent aphthous stomatitis, even though it is a vasculitis of rare occurrence in early life. METHODS Between June 1996 and December 2000, we retrospectively evaluated seven patients of our Pediatric Rheumatology Unit. Demographic, clinical, and laboratory...

BACKGROUND/AIM Recurrent aphthous stomatitis (RAS) is defined as multifactor immunologic inflammatory lesions in the oral cavity, characterized by painful, recurrent single/multiple, shallow, round or ovoid ulcerations of mucosal tissues. To date, a considerable number of RAS treatment protocols have been suggested, but since the etiology of RAS is idiopathic, these treatment options have sympt...

Introduction PFAPA syndrome is the most common autoinflammatory fever disorder in childhood, characterized by recurrent fever, aphthous stomatitis, pharyngitis and adenitis. Mutations in the MEFV and NLRP3 genes are known to cause syndromes with PFAPA overlapping symptoms (Familial Mediterranean Fever and Cryopyrin-Associated Periodic Syndrome), which are rarely reported in patients from Slovenia.