The solubility, absorption and distribution of a drug are involved in the basic aspects of oral bioavailability Solubility is an essential characteristic and influences the efficiency of the drug. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing oral bioavaibility is the technique of nanoparticle preparation, which al...

Ribonucleoprotein particles were prepared by treatment of rat liver microsomes with detergents and high concentrations of KCl. They were active in incorporating (14)C amino acids into protein when incubated with cell sap together with ATP, GTP, and a system to regenerate the triphosphates. The albumin of the incubation mixture, soluble at 105,000 g, and that of the fraction released by ultrason...

in comparison to the previous researches, zro2 nanoparticles with higher surface area (85 m2/g) have been synthesized in this research. the as-prepared zro2 nanoparticles by co-precipitation method were characterized with x-ray diffraction (xrd), scanning electron microscopy (sem) and transmission electron microscopy (tem). the surface area of the sample was characterized by bet method. the eff...

Antisolvent crystallization is a separation technology that separates the solute from solvent by addition of another solvent, in which sparingly soluble. High yields are achieved using higher antisolvent-to-aqueous ratios, but this generates supersaturation, causes excessive nucleation. This results production smaller particles, difficult to handle downstream processes. In work, effect varying ...

Background: Cotton gin trash (CGT) is a lignocellulosic residue that can be used in the production of cellulosic ethanol. In a previous research, the sequential use of ultrasonication, liquid hot water, and ligninolytic enzymes was selected as pretreatment for the production of ethanol from CGT. However, an increment in the ethanol production is necessary. To accomplish that, this research eval...

ABSTRACT
 Objective: In this study, it was aimed to prepare nanosuspensions that contains Indomethacin which is a BCS class II drug. To assess the cumulative impact of chosen variables on nanosuspension properties, 34 factorial design applied and particle size distributions were examined.
 Material Method: solvent/antisolvent method used in preparation suspensions. design. Design-Expe...

Uncertainty of complete recovery of attached bacteria during extraction is a major problem in the enumeration of these microorganisms. Homogenization and ultrasonication are the most commonly used physical techniques of extraction, and each is used on the assumption that it gives maximum yield. Ultrasonication of formalin-fixed sandy sediments using an ultrasonication bath with a frequency rang...

In this paper, we describe a novel technique--ultrasonication-assisted spray ionization (UASI)--for the generation of singly charged and multiply charged gas-phase ions of biomolecules (e.g., amino acids, peptides, and proteins) from solution; this method employs a low-frequency ultrasonicator (ca. 40 kHz) in place of the high electric field required for electrospray ionization. When a capillar...