BACKGROUND Herb-drug interactions are an important issue in drug safety and clinical practice. The aim of this epidemiological study was to characterize associations of clinical outcomes with concomitant herbal and antipsychotic use in patients with schizophrenia. METHODS AND FINDINGS In this retrospective, cross-sectional study, 1795 patients with schizophrenia who were randomly selected fro...

clozapine is the first antipsycotic drug with a great efficacy. thirty to fifty percent of treatment-resistant schizophrenics markedly improved with clozapine. approximately, 25% of long-term patients, treated with clozapine, could be discharged. this improvement included negative as well as positive symptom areas. clozapine produced no extrapyramidal side effects. tardive dyskinesia, a major s...

OBJECTIVES To investigate the association between use of typical and atypical antipsychotic drugs and incidence of stroke in patients with and without dementia. DESIGN Self controlled case series. SETTING UK based electronic primary care records in the general practice research database (GPRD). PARTICIPANTS All patients registered in the database with a recorded incident stroke and at lea...

WARNING Increased Mortality in Elderly Patients with Dementia-Related Psychosis — Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1....

Cognitive enhancement has become an important target for drug therapies in schizophrenia. Treatment development in this area requires assessment approaches that are sensitive to procognitive effects of antipsychotic and adjunctive treatments. Ideally, new treatments will have translational characteristics for parallel human and animal research. Previous studies of antipsychotic effects on cogni...