Drug repurposing approaches have the potential advantage of facilitating rapid and cost-effective development of new therapies. Particularly, the repurposing of drugs with known safety profiles in children could bypass or streamline toxicity studies. We employed a phenotypic screening paradigm on a panel of well-characterized cell lines derived from pediatric solid tumors against a collection o...

With at least 60% of the Millettia species (Fabaceae) being in medicinal use, we found it relevant to assess the potential antiprotozoal and antifungal activities of Millettia richardiana. Water and methanol crude extracts of the stem barks from M. richardiana and the six fractions resulting from the fractionation of the methanol extract were tested. The dichloromethane extracted fraction showe...

Abstract Aspirin is one of the most widely used medications globally as an analgesic and antipyretic drug. use antiparasitic against fish parasites has never been tested. The parasite Dactylogyrus considered a serious threat to freshwater aquaculture in relation considerable losses. present study aimed evaluate effect aspirin extensus on Cyprinus carpio alteration gill histopathology. In vitro ...

The main objective of this article is to explore the available classified information on Zingiber aromaticum Val. Rhizome and its active compound, Zerumbone. Throughout history, plant has been utilized treat various ailments such as abdominal disorders, cough, anemia, malaria, jaundice, arthritis, infections. Recently, Zerumbone, a sesquiterpene compound found in rhizomes, gained attention for ...

Schistosomiasis, caused by the parasitic flatworm Schistosoma mansoni and related species, is a tropical disease that affects over 200 million people worldwide. A new approach for targeting eukaryotic parasites is to tackle their dynamic epigenetic machinery that is necessary for the extensive phenotypic changes during the life cycle of the parasite. Recently, we identified S. mansoni histone d...

In countries where leishmaniasis is endemic, there are not very many treatment alternatives and most options have problems associated with their use. Plants and their natural products constitute good sources of interesting lead compounds that could be potentially active against Leishmania. Chenopodium ambrosioides is a plant that is widely used in popular medicine and its antiparasitic effects ...

The effect of culture conditions on the production of bioactive secondary metabolites by the endophytic fungus Arthrinium state of Apiospora montagnei Sacc. was investigated. Culture broths were partitioned with ethyl acetate and the resulting extracts were evaluated for antibacterial, antifungal, cytotoxic, and antiparasitic activities. The highest levels of activities were arisen from culture...

Toxoplasma gondii is an obligate intracellular parasite that can cause disease in the developing fetus and in immunocompromised humans. Infections can last for the life of the individual, and to date there are no drugs that eliminate the chronic cyst stages that are characteristic of this parasite. In an effort to identify new chemical scaffolds that could form the basis for new therapeutics, w...