Antioxidant enzyme activities, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and total glutathione concentration were determined in guinea pig lung and liver over the final period of gestation (days 50-68) and at several ages post-partum. Pulmonary antioxidant capacity increased markedly over the final days of gestation, individual changes ranging from 29% (glutath...

Superoxide dismutases (SODs) represent the major antioxidant defense system against superoxide anions (O2 ). Three isoforms of superoxide dismutase have been identified in mammals: copper-zinc SOD (Cu, ZnSOD), manganese SOD (Mn-SOD), and extracellular SOD (ecSOD). Cu, Znand Mn-SOD are localized intracellularly, whereas the last discovered SOD isoform, ecSOD,1 is secreted and bound to heparan su...

the p63 gene, a member of the p53 gene family, is expressed into at least six protein isoforms.the transcription factor p63 is a homologue of the tumor suppressor p53. unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate. p63, , is transcribed from two different promoters giving rise...

abstract     crop residues are well known for their chemical (allelopathic) effects on crops. the allelopathic potential of the aqueous extracts and chopped residual of sorghum (sorghum bicolor l.) on germination, seedling growth, relative water content, seedling dry weight, seedling length and antioxidant enzyme activity namely catalase (cat), peroxidase (pod) and superoxide dismutase (sod) of...

background: aging contains morphological and functional deterioration in biological systems. d-galactose (d-gal) generates free radicals and accelerates aging. portulaca oleracea (purslane) may have protective effect against oxidative stress. objective: purslane ethanolic extract effects were evaluated on antioxidant indices and sex hormone in d-gal aging female mice. materials and methods: 48 ...

Peroxiredoxins (PRDXs), a ubiquitous family of redox-regulating proteins, are reported of potential to eliminate various reactive oxygen species (ROS). As a major member of the antioxidant enzymes, PRDX1 can become easily over-oxidized on its catalytically active cysteine induced by a variety of stimuli in vitro and in vivo. In nucleus, oligomeric PRDX1 directly associates with p53 or transcrip...

AIM To investigate the role of erythrocyte free radical scavenging enzyme activities (FRSE), carbonic anhydrase (CA) activity and malondialdehyde (MDA) in infants with myelomeningocele (MM). MATERIAL AND METHODS We compared antioxidant enzyme activities and MDA level in 40 individuals (10 infants with MM, 10 healthy infants; and mothers of these two groups) with age-matched subjects. Erythroc...

Transcripts of the UGT1A gene, encoding half of human UDP-glucuronosyltransferase (UGT) enzymes, undergo alternative splicing, resulting in active enzymes named isoforms 1 (i1s) and novel truncated isoforms 2 (i2s). Here, we investigated the effects of depleting endogenous i2 on drug response and attempted to unveil any additional biologic role(s) for the truncated novel UGT proteins. We used a...

BACKGROUND Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (ARE)-dependent genes. OBJECTIVES We investigated the role of NRF1 in arsenic-...