Acting as a signal, hydrogen peroxide circumvents antioxidant defense by overoxidizing peroxiredoxins (Prxs), the enzymes that metabolize peroxides. We show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of Prxs containing Cys-SO(2)H, thus reestablishing the antioxidant firewall. Sestrins contain a predicted redox-active domain homologous...

Oxidative damage has been proposed as one of the possible mechanism involved in the nephrotic syndrome. Strengthening the defense system by antioxidants may provide protection against oxidative damage. Therefore, this study was carried out to investigate oxidant and antioxidant status with copper, zinc and homocysteine in nephrotic syndrome patients and the effect of antioxidants, minerals and ...

Drought is one of the major environmental problems in agricultural field worldwide. The present study investigated the effects of water deficit caused by exogenous application of polyethylene glycol (PEG) on cabbage (Brassica oleracea var. capitata) grown in hydroponic culture. Root length, shoot length, dry weight, and relative water content of the seedlings significantly decreased in dose dep...

Coronavirus disease 2019 (COVID-19), is an infectious with various clinical presentation from asymptomatic to severe pneumonia and death. It caused by the infection of acute respiratory syndrome coronavirus-2 (SARS-CoV-2). One important mechanisms that underlies COVID-19 oxidant-antioxidant imbalances owing inflammatory response excessive oxidative stress. The antioxidant defense system plays a...

Selenium is a fundamental importance to human health. It is an essential trace element for major metabolic pathways, since selenium is an essential component of glutathione peroxidase enzyme. Diet is the main source of selenium. Selenoproteins in mammalian cells indicated that essential role of selenium in the body’s antioxidant defense system.

Superoxide dismutases (SODs) represent the major antioxidant defense system against superoxide anions (O2 ). Three isoforms of superoxide dismutase have been identified in mammals: copper-zinc SOD (Cu, ZnSOD), manganese SOD (Mn-SOD), and extracellular SOD (ecSOD). Cu, Znand Mn-SOD are localized intracellularly, whereas the last discovered SOD isoform, ecSOD,1 is secreted and bound to heparan su...

In vitro maturation (IVM) is emerging as a popular technology at the forefront of fertility treatment and preservation. However, standard in vitro culture conditions usually increase reactive oxygen species (ROS), which have been implicated as one of the major causes for reduced embryonic developmental competence. It is well-known that higher than physiological levels of ROS triggers granulosa ...