The study was designed with an aim to evaluate the antiperoxidative potential of ascorbic acid on busulfan-induced lipid peroxidation. The study was performed in vitro using goat liver as lipid source. This evaluation was done by measuring the 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of liver tissue homogenates as markers of lipid peroxidation. The study reveals the lipid perox...

BACKGROUND Dental caries is a major problem in preschool children. The contribution of saliva in providing defense during caries process is of primary importance. pH buffer capacity through bicarbonate, phosphate and protein buffer systems have universal acceptance as a caries defense mechanism. Antioxidant capacity of saliva can constitute a first line of defense against chronic degenerative d...

BACKGROUND Normal and pathological processes entail the production of oxidative substances that can damage biological molecules and harm physiological functions. Organisms have evolved complex mechanisms of antioxidant defense, and any imbalance between oxidative challenge and antioxidant protection can depress fitness components and accelerate senescence. While the role of oxidative stress in ...

The present investigation was executed with an objective to study the effects of Co stress in Arachis hypogaea L. with special emphasis on antioxidant enzymes activities which are the defense mechanism to any type of abiotic stress. In this we have analysed the effect of cobalt (Co) stress on antioxidant enzyme activities (catalase, peroxidase and polyphenol oxidase) of Arachis hypogaea L. were...

Oxidative stress response in plants is still poorly understood in comparison with the correspondent phenomenon in bacteria, yeast and mammals. For instance, nitric oxide is assumed to play various roles in plants although no nitric oxide synthase gene has yet been isolated. This research reports the results of a search of the sugarcane expressed sequence tag (SUCEST) database for homologous seq...

Introduction: Diabetes mellitus is a metabolic disorder and it is estimated that its annual incidence rate will continue to increase in the future worldwide. Increased oxidant factors and decreased antioxidant defense are two of the factors resulting in diabetes. In the present study, we aimed to investigate Citrullus Colocynthis pulp effects on oxidant and antioxidant factors of liver in st...

Currently, food security depends on the increased production of cereals such as wheat (Triticum aestivum L.), which is an important source of calories and protein for humans. However, cells of the crop have suffered from the accumulation of reactive oxygen species (ROS), which can cause severe oxidative damage to the plants, due to environmental stresses. ROS are toxic molecules found in variou...

Premature infants < 32 weeks’ gestation often require resuscitation during fetal to neonatal transition, which includes administration of supplemental oxygen. Hyperoxia is one of the important generators of reactive oxygen species (ROS) and excess ROS is kept in check by antioxidant defense mechanisms. Premature infants have reduced antioxidant defense mechanisms at birth and hence are at risk ...

Hydrogen peroxide is most stable molecule among reactive oxygen species, which play a vital role in growth and development of plant as signaling molecule at low concentration in response to various abiotic and biotic stresses. Exogenous application of H2O2 is known to induce chilling tolerance in plants. Brassinosteroids are plant steroid hormones known for their anti-stress properties. In this...

Stationary-phase bacteria are important in disease. The σ(s)-regulated general stress response helps them become resistant to disinfectants, but the role of σ(s) in bacterial antibiotic resistance has not been elucidated. Loss of σ(s) rendered stationary-phase Escherichia coli more sensitive to the bactericidal antibiotic gentamicin (Gm), and proteomic analysis suggested involvement of a weaken...