Cycloheximide, at a protein-inhibitory concentration, when given to rabbit kidney cell cultures that had been exposed either to UV-irradiated Newcastle Disease virus or to a complex of polyinosinic and polycytidylic acids (poly I.poly C), enhanced the production of interferon. The enhancement was greater if, in addition to cycloheximide, the cells were also treated with actinomycin D. On the ba...

Methotrexate (MTX) belongs to a group of drugs known as antimetabolites and is a structural analog of folic acid. It was used for the first time for the treatment of psoriasis over 50 years ago. Nowadays it is used in every type of moderate-to-severe psoriasis, including psoriatic arthritis, and is considered as the most effective disease modifying drug (DMARD). In this paper we review the curr...

Mouse blastocysts in culture have been treated with increasing concentrations of cytosine arabinoside, bromodeoxyuridine or Colcemid. Concentrations of all three antimetabolites have been found which interfere with neither hatching of the blastocysts from their zona pellucidae nor subsequent attachment of the blastocysts to the culture dish, but which eventually result in death of the inner cel...

Abstract Background and Aims Longer survival in renal transplantation means an increase the number of patients who return to dialysis after graft loss. There is little literature about management immunosupression(IS) these complications derived from its maintenance withdrawal/reduction. Method We conducted a retrospective study involving cohort returned failure at Doce de Octubre Hospital 2015 ...

Chemotherapy may be indicated for the treatment of cancer during pregnancy. The decision to use chemotherapy significantly impacts the pregnancy, and in turn the pregnancy may affect the treatment options available to patients with cancer. This review provides information about the effects of chemotherapeutic agents in pregnancy, taking into account both the mother and the fetus. For convenienc...

Non infectious vitreous inflammation is often vision threatening and can be associated with potentially life-threatening systemic conditions. Treatment is often challenging as it involves systemic medications that can be associated with adverse effects. The classes of drugs are ever expanding and include corticosteroids, antimetabolites, alkylating agents, T-cell and calcineurin agents, biologi...

5′-Methylthioadenosine (MTA) is a natural substrate of MTA phosphorylase (MTAP) and converted to adenine via salvage pathway for AMP production in normal healthy cells. The lack MTAP expression many solid tumors hematologic malignancies compared cells has been explored potential therapeutic strategy selectively target tumor using antimetabolites such as 5-fluorouracil (5-FU) 6-thioguanine (6-TG...

Radiomimetic substances are drugs producing similar symptoms in living organisms as ionising radiation does. They constitute a special subgroup of carcinogen, mutagen, teratogen compounds; their common characteristic is to cause DNA breaks and/or inhibit repair. Mustard gas and its derivatives – alkylating agents were the first known group radiomimetic substances, later, it was observed, that s...