OBJECTIVE To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. METHOD Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. RESULTS DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum ...

Cassia spectabilis is one of the Indonesian medicinal plants traditionally used to treat different diseases, including malaria. Quality a drug derived from also influenced by quality its raw materials. Thus, in order assure products made plants, it necessary standardize materials and following with antimalarial activity test. The aim this study was C. leaves evaluate activities ethyl acetate ex...

The major bioactive compounds in S. chirayita are amarogentin (most bitter compound) and mangiferin, which contribute to its medicinal value due antidiabetic, anticancer, antimicrobial antimalarial properties. In this study, we developed a light emitting diode (LED)–based culture setup as an alternative the existing white fluorescent lamps (WFL) used source tissue conditions of plants. in-vitro...

Malaria remains o n e o f the leading causes of morbidity and mortality in tropical countries, and the alarming spread of the drugs resistant malaria parasite underscores the need to develop new antimalarial compounds. In this study, the phytochemical constituents, in vivo antiplasmodial, and cytotoxic activity of methanolic extracts of Achyranthes aspera and Ficus thoningii were evaluated usin...

Background: This research deals with the indigenous medicinal plants used by rural population of Artvin-Borçka (Zorlu village), for treatment gynecological disorders. For this purpose, ethnomedicinal survey Zorlu village in Turkey was carried out during 2008-2009. Methods: In present study, a two-part made. The first part determined folk medicine Second were uses plants. Results: Local inhabita...

Many developing countries including Cameroon have mortality patterns that reflect high levels of infectious diseases and the risk of death during pregnancy and childbirth, in addition to cancers, cardiovascular diseases and chronic respiratory diseases that account for most deaths in the developed world. Several medicinal plants are used traditionally for their treatment. In this review, plants...

alcoholic extracts of 8 different types of seaweeds from iran's persian gulf were tested for their antimalarial and acetylcholinesterase enzyme (ache) inhibitory activities for the first time. a modified ellman and ingkaninan method was used for measuring ache inhibitory activity in which galanthamine was used as the reference. the antimalarial assay was performed using microculture radioisotop...

The prevalence of resistance to known antimalarial drugs has resulted in the expansion of antimalarial drug discovery efforts. Academic and nonprofit institutions are partnering with the pharmaceutical industry to develop new antimalarial drugs. Several new antimalarial agents are undergoing clinical trials, mainly those resurrected from previous antimalarial drug discovery programs. Novel anti...

The evaluation of new antimalarial agents using older methods of monitoring sensitivity to antimalarial drugs are laborious and poorly suited to discriminate stage-specific activity. We used flow cytometry to study the effect of established antimalarial compounds, cysteine protease inhibitors, and a quinolone against asexual stages of Plasmodium falciparum. Cultured P. falciparum parasites were...