Promethazine hydrochloride is a first-generation H1 receptor antagonist, antihistamine, and antiemetic medication that can also have strong sedative effects. The apparent ability of topical H1r/2r antagonists to target epidermal H1/2r was translated into increased efficacy in the treatment of inflammatory dermatoses, likely due to decreased inflammation and enhanced barrier function.

Address for correspondence: Dr Eleonora Nucera, Allergy Unit, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli”, Largo F. Vito, 1-00168 Rome, Italy, phone: +39 0630154965, fax: +39 0630156999, e-mail: [email protected] Received: 10.02.2016, accepted: 9.07.2016. Anaphylaxis by antihistamine containing bovine gelatin: the utility of the basophil activation test in the dia...

Acquired neuromuscular weakness often develops in patients with an acute respiratory distress syndrome (ARDS), particular who are ventilated and sedated for long periods. This has been rarely described the literature on ARDS secondary to SARS-CoV-2 infection. Our clinical case revealed existence of these manifestations COVID-19 disease after use hydroxyzine, antihistamine whose side-effects unk...

Lena Olsén 2007. Drugs in horses: pharmacokinetics and pharmacodynamics Doctoral thesis ISSN 1652-6880, ISBN978-91-576-7336-7 In this thesis the fate and effect of some drugs have been examined in horses. Studies have also been performed to explore some factors which may affect the pharmacokinetics and the pharmacodynamics of drugs in horses. Investigations on the drug metabolising enzyme cytoc...

BACKGROUND Several studies suggest that Vitamin D (Vit-D3) supplementation reduces Chronic Urticaria (CU) symptoms. OBJECTIVES Evaluation of serum 25-hydroxyvitamin-D (25 (OH)2D) level and assessment of therapeutic effect of VitD3in CU patients. METHODS 192 subjects were stratified according to the baseline 25(OH)2D levels and subsequently randomized into three subgroups to receive Vit-D3 a...

BACKGROUND Many physicians believe that the most effective way to treat chronic urticaria is to take a nonsedating second-generation H1 -antihistamine in the morning and a sedating first-generation H1 -antihistamine, usually hydroxyzine, at night to enhance sleep. But is this belief well founded? OBJECTIVES To test this belief by comparing the effectiveness and prevalence of unwanted sedative...