نتایج جستجو برای: antigen heterogeneity
تعداد نتایج: 293253 فیلتر نتایج به سال:
Selective breeding of rabbits immunized with Group C and Group A streptococcal vaccines was employed to reveal genetic influences on the magnitude and on the restriction in heterogeneity of the immune response to the group-specific carbohydrates. After two generations of selective breeding, complete segregation was achieved between a high-response population (>18 mg precipitins/ml serum, averag...
Abstract Chimeric antigen receptor (CAR)-T cells have had a significant effect in hematological diseases, with recent study confirming that the can last for ten years vivo. Unfortunately, to date, CAR-T little solid tumors. One cause of treatment difficulty is antigenic heterogeneity. Our experience glioblastoma suggests addressing heterogeneity may improve clinical efficacy. Targeting epiderma...
The leukemic population in 63 patients with acute myeloid leukemia (AML) was studied with 15 monoclonal antibodies that detect lineage-related and stage-related antigens on normal hemopoietic cells. Indirect immunofluorescence and fluorescence-activated cell sorting showed that subpopulations of leukemic cells reacted with some or all antibodies, but the percentage of cells reacting with a sing...
Telomeres have been shown to gradually shorten during replicative aging in human somatic cells by Southern analysis. This study examines telomere shortening at the single cell level by fluorescence in situ hybridization (FISH). FISH and confocal microscopy of interphase human diploid fibroblasts (HDFs) demonstrate that telomeres are distributed throughout the nucleus with an interchromosomal he...
Abstract To gain mechanistic insights into the functions and developmental dynamics of tumor-infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA-sequencing antigen receptor lineage analysis to characterize a large number triple-negative breast cancer infiltrated cells report comprehensive atlas B-lymphocytes. The transcriptional profiles reveal significant hetero...
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