The very first edition of this classic text in tropical diseases appeared in 1898 under the authorship of the legendary "father of tropical medicine," Sir Patrick Manson, who nurtured this book through six editions until his death in 1922. For over eighty years students of tropical diseases have turned to its previous editions to familiarize themselves with these important disease entities. The...

leptospirosis is one of the most prevalent zoonotic diseases worldwide. currently, multivalent whole-cell leptospiral vaccines can induce protection against leptospirosis. therefore, preparation and formulation of new generations of vaccines that can stimulate long-term immunity for leptospirosis control are essential. the aim of this study was to prepare and characterize alginate microspheres ...

the liver fluke fasciola hepatica causes fascioliasis, a liver disease in most part of the world and particularly in north of iran. diagnosis of the diseases is anchored in coprological manner but serological methods are preferable due to some obscurities. in this study, sera obtained from human patients infected with fasciola hepatica were tested by the enzymelinked immunotrotransfer blot (eit...

The conventional anti-Bartonella henselaeIgM enzyme-linked immunosorbent assay (IgM-ELISA) methods for diagnosing cat scratch disease (CSD) remain poor in both sensitivity and specificity. We sought to develop an IgM-ELISA with improved accuracy in the serodiagnosis of CSD by exploring the antigens that are most suitable for an ELISA. We prepared 5 different protein antigens: antigen I (sonicat...

Antifungal treatment reduces the concentration of Histoplasma antigen in blood and urine, supporting a hypothesis that antigen clearance could be used to compare the activity of new agents for treating histoplasmosis. In separate trials in patients with AIDS, clinical response was similar with itraconazole (85%) and fluconazole (74%). Fungal blood cultures at week 4, however, were negative in a...

A major obstacle to development of subunit vaccines and diagnostic reagents for tuberculosis is the inability to produce large quantities of these proteins. To test the hypothesis that poor expression of some mycobacterial genes in Escherichia coli is due, in part, to the presence of low-usage E. coli codons, we used site-directed mutagenesis to convert low-usage codons to high-usage codons for...

BACKGROUND Bronchial epithelial cells (BEC) are primary target for Rhinovirus infection through attaching to cell membrane proteins. OM-85, a bacterial extract, improves recovery of asthma and COPD patients after viral infections, but only part of the mechanism was addressed, by focusing on defined immune cells. OBJECTIVE We therefore determined the effect of OM-85 on isolated primary human B...

BACKGROUND Methods to determine the microbial cause of community acquired pneumonia include detection of pneumococcal antigen and measurement of pneumococcal capsular antibody response. Their usefulness compared with conventional microbiological techniques was investigated in patients with pneumonia, some of whom had been treated with antibiotics. METHODS Pneumococcal capsular antigen was det...

Aalders JG 1627 Aas T 74 Abbou CC 1515 Abdulkarim B 2017 Abeliovich D 36 Adami H-O 678, 1317 Adams LM 1403 Adjei AA 484 Adjuvant Breast Cancer Project Belgium 1 Agelaki S 798 Aguggini S 1106 Agus V 1535 Ahern R 953 A’Hern R 1383 Aherne GW 446 Ahlner-Elmqvist M 1478 Ahmad SA 584 Ahmed A 1667 Aillet G 1831 Aine R 552 Akahira J 1731 Al-Mulla F 692, 1032 Alakhov VY 1987 Ali MS 661 Allen-Mersh TG 16...

Accelerated chemotherapy 1444 Acquired resistance 1064 ADCC 463 Adenocarcinomas 1023, 1153, 1371, 1781 Adenomatous polyposis coli 69, 98 Adjuvant chemotherapy 827, 1251 Adjuvant therapy 1437 Advanced breast cancer 141 Advanced gastrointestinal cancer 1265 Aetiology 1667 Ageing 930 Aggressive fibromatosis 98 AIDS 1298 Alcohol 46, 341, 678 Alcohol intake 1700 ALIMTA 649 Allelic imbalance 1201 Alp...