The goal in treatment of infections is to achieve a beneficial effect while minimizing toxicity. It is widely recognized that the principles of pharmacokinetics and pharmacodynamics are critical to determining an adequate dose-response relationship. There has been an increased involvement of the CNS to infection from opportunistic and endemic fungi over the last several decades due to establish...

OBJECTIVES Antifungal prescription practices have changed over the last decade, and the impact of these changes is unclear. Our objective here was to evaluate the effect of antifungal drug use on the distribution and drug susceptibility of Candida spp. in a French intensive care unit (ICU). METHODS Antifungal drug use was measured as the number of defined daily doses per 1000 hospital days (D...

In order to use natural compounds in controlling plant pests and diseases, many researchers in recent years have studied the antifungal effects of essential oils and plant extracts.  The purpose of this study was to investigate the chemical composition and antifungal effects of Echium khuzestanium and marubbium anisodan extracts. After extraction and preparation of di...

Orange peel extract solution contains mucilage flavor and three types of glycosides. Limonene is one of the terpenoides in some vegetables, fruits and food; that plays as an antioxidant in juice. As it has anti-microorganism effects on some bacteria, we carried out the antifungal effects of limonene versus orange extract. In the present study the effects of orange extract and two types of limon...

Cutaneous fungal infections remain a clinical problem. Among fungi, dermatophyte molds are the major cause of various type of Tinea. These infections are still difficult to manage and some of the antifungal agent are poorly tolerated or have been associated with emergence of resistance. The traditional methods, especially the use of medicinal plants place an imperative role to cover the basic h...

Cutaneous fungal infections remain a clinical problem. Among fungi, dermatophyte molds are the major cause of various type of Tinea. These infections are still difficult to manage and some of the antifungal agent are poorly tolerated or have been associated with emergence of resistance. The traditional methods, especially the use of medicinal plants place an imperative role to cover the basic h...

Aim: This study was performed to isolate antifungal substance from actinomycetes species found in soil in order to avoid osmophilic food spoilage. Methods: Purified isolates of different actinomycetes collected from soil in Makkah region, Saudi Arabia were screened for their antifungal bioactivity against the unicellular fungal strain, Saccharomyces cerevisiae. The actinomycete isolate that sho...

The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

AIMS To characterize and explore the potential in extracellular biosynthesis of silver nanoparticles (AgNPs) by Penicillium chrysogenum and Aspergillus oryzae and to investigate the antifungal effect of chemically vs biologically synthesized AgNPs comparing with conventional antifungal drugs against Trichophyton rubrum. METHODS AND RESULTS Chemically synthesized AgNPs (Chem-AgNPs) coated with...

In recent years, the use of antifungal drugs in human medicine has increased, especially with the advent of AIDS epidemic. Efforts have focused on the development of new, less toxic and more efficacious antifungal drugs with novel mechanism of action. The purpose of this study was to synthesize of some new benzimidazole, benzotriazole and aminothiazole derivatives and to evaluate their activity...