BACKGROUND Several reports of various bleeding problems associated with the use of serotonergic antidepressants have been published. However, no information concerning the effect of these drugs on perioperative blood loss and blood transfusion requirements during orthopedic surgery is available. The objective of this study was to determine the association between use of serotonergic antidepress...

Depression and dementia are common comorbidities among Nursing Home (NH) residents. Antidepressants are widely used in this vulnerable population. However, the evidence for anti-depressant use, including from randomized controlled trials, systematic reviews, and evidence-based clinical practice guidelines, is inconsistent and conflicting. Additionally, antidepressants are associated with multip...

OBJECTIVES Several studies suggested that antidepressant use may increase or decrease the risk of cancer occurrence, depending on specific cancer types. The possible carcinogenic effect of antidepressants has received substantial attention; however, evidence remains inconclusive. Here we investigated associations between the use of antidepressants and occurrences of oral cancer (OC). METHODS ...

BACKGROUND The U.S. Food and Drug Administration recently extended the Black Box warning on anti-depressants regarding pediatric suicidality to include young adults. The decision was guided by results from meta-analyses of 372 randomized controlled clinical trials of antidepressants for adults. Nearly all suicidality in those trials was nonfatal suicide attempts and ideation. Here, we consider ...

This study examined whether antidepressants delay the need for dopaminergic therapy or change the degree of motor impairment and disability in a population of early Parkinson's disease (PD) patients. Preclinical studies have indicated that antidepressants modulate signaling pathways involved in cell survival and plasticity, suggesting they may serve to both treat PD-associated depression and sl...

Antidepressants, given systemically, are widely used for the treatment of various chronic and neuropathic pain conditions in humans. In animal studies, antidepressants exhibit analgesic properties in nociceptive, inflammatory and neuropathic test systems, with outcomes depending on the specific agent, the particular test, the route of administration and the treatment method used. Although early...

BACKGROUND AND PURPOSE Although depression may affect recovery and outcome after stroke, it is often overlooked or inadequately managed, and there is uncertainty regarding the benefits of antidepressant therapy in this setting. We aimed to assess the effectiveness of antidepressants for the treatment and prevention of depression after stroke. METHODS We undertook a systematic review using Coc...

Although antidepressants may increase the risk of switching to mania in bipolar disorder (BD), clinicians have been using antidepressants to treat patients with bipolar depression. Appropriate treatments for bipolar depression remain controversial. In BD, antidepressants comprise a double-edged sword in terms of their efficacy in treating depression and the increased risk of switching. This rev...

FOR HKMA Antidepressant drugs have unique toxicities that are based on their pharmacology and determine their specific treatment. There are currently 4 classes of antidepressant drugs: monoamine oxidase inhibitors, cyclic antidepressants, selective serotonin reuptake inhibitors, and the atypical antidepressants which include a variety of other drugs. The selective serotonin reuptake inhibitors ...